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Mouse Anti-PSMC3IP Recombinant Antibody (CBYJT-1604) (CBMAB-T0647-YJ)

Provided herein is a Mouse monoclonal antibody, which binds to PSMC3IP (PSMC3 Interacting Protein). The antibody can be used for immunoassay techniques, such as WB, IP, IF, ELISA.
See all PSMC3IP antibodies

Summary

Host Animal
Mouse
Specificity
Human
Clone
CBYJT-1604
Antibody Isotype
IgG
Application
WB, IP, IF, ELISA

Basic Information

Specificity
Human
Antibody Isotype
IgG
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Buffer
PBS, pH 7.4
Storage
Store at 4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
PSMC3 Interacting Protein
Introduction
PSMC3IP plays an important role in meiotic recombination. Stimulates DMC1-mediated strand exchange required for pairing homologous chromosomes during meiosis. The complex PSMC3IP/MND1 binds DNA, stimulates the recombinase activity of DMC1 as well as DMC1 D-loop formation from double-strand DNA. This complex stabilizes presynaptic RAD51 and DMC1 filaments formed on single strand DNA to capture double-strand DNA. This complex stimulates both synaptic and presynaptic critical steps in RAD51 and DMC1-promoted homologous pairing. It may inhibit HIV-1 viral protein TAT activity and modulate the activity of proteasomes through association with PSMC3. acts as a tissue specific coactivator of hormone-dependent transcription mediated by nuclear receptors.
Entrez Gene ID
29893
UniProt ID
Q9P2W1
Alternative Names
HOP2; ODG3; GT198; TBPIP; HUMGT198A
Function
Plays an important role in meiotic recombination. Stimulates DMC1-mediated strand exchange required for pairing homologous chromosomes during meiosis. The complex PSMC3IP/MND1 binds DNA, stimulates the recombinase activity of DMC1 as well as DMC1 D-loop formation from double-strand DNA. This complex stabilizes presynaptic RAD51 and DMC1 filaments formed on single strand DNA to capture double-strand DNA. This complex stimulates both synaptic and presynaptic critical steps in RAD51 and DMC1-promoted homologous pairing. May inhibit HIV-1 viral protein TAT activity and modulate the activity of proteasomes through association with PSMC3. Acts as a tissue specific coactivator of hormone-dependent transcription mediated by nuclear receptors.
Biological Process
Homologous chromosome pairing at meiosisManual Assertion Based On ExperimentIDA:ComplexPortal
Meiotic joint molecule formationManual Assertion Based On ExperimentIBA:GO_Central
Meiotic strand invasion involved in reciprocal meiotic recombinationManual Assertion Based On ExperimentIBA:GO_Central
Reciprocal meiotic recombinationManual Assertion Based On ExperimentIDA:ComplexPortal
Cellular Location
Nucleus
Involvement in disease
Ovarian dysgenesis 3 (ODG3):
A disorder characterized by lack of spontaneous pubertal development, primary amenorrhea, uterine hypoplasia, and hypergonadotropic hypogonadism as a result of streak gonads.
PTM
PTM: Phosphorylated by PKA, PKC and MAPK.
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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