PSPH

The protein encoded by this gene belongs to a subfamily of the phosphotransferases. This encoded enzyme is responsible for the third and last step in L-serine formation. It catalyzes magnesium-dependent hydrolysis of L-phosphoserine and is also involved in an exchange reaction between L-serine and L-phosphoserine. Deficiency of this protein is thought to be linked to Williams syndrome. [provided by RefSeq]

phosphoserine phosphatase

Catalyzes the last irreversible step in the biosynthesis of L-serine from carbohydrates, the dephosphorylation of O-phospho-L-serine to L-serine (PubMed:12213811, PubMed:15291819, PubMed:9222972, PubMed:14673469, PubMed:25080166).
L-serine can then be used in protein synthesis, to produce other amino acids, in nucleotide metabolism or in glutathione synthesis, or can be racemized to D-serine, a neuromodulator (PubMed:14673469).
May also act on O-phospho-D-serine (Probable).

DephosphorylationManual Assertion Based On ExperimentIBA:GO_Central
In utero embryonic developmentIEA:Ensembl
L-serine biosynthetic processManual Assertion Based On ExperimentIMP:UniProtKB
L-serine metabolic processManual Assertion Based On ExperimentIDA:UniProtKB
Response to mechanical stimulusIEA:Ensembl
Response to nutrient levelsIEA:Ensembl
Response to testosteroneIEA:Ensembl

Cytoplasm, cytosol

Phosphoserine phosphatase deficiency (PSPHD):
An autosomal recessive disorder that results in pre- and postnatal growth retardation, moderate psychomotor retardation and facial features suggestive of Williams syndrome.