PSPH

The protein encoded by this gene belongs to a subfamily of the phosphotransferases. This encoded enzyme is responsible for the third and last step in L-serine formation. It catalyzes magnesium-dependent hydrolysis of L-phosphoserine and is also involved in an exchange reaction between L-serine and L-phosphoserine. Deficiency of this protein is thought to be linked to Williams syndrome. [provided by RefSeq]
Full Name
phosphoserine phosphatase
Function
Catalyzes the last irreversible step in the biosynthesis of L-serine from carbohydrates, the dephosphorylation of O-phospho-L-serine to L-serine (PubMed:12213811, PubMed:15291819, PubMed:9222972, PubMed:14673469, PubMed:25080166).
L-serine can then be used in protein synthesis, to produce other amino acids, in nucleotide metabolism or in glutathione synthesis, or can be racemized to D-serine, a neuromodulator (PubMed:14673469).
May also act on O-phospho-D-serine (Probable).
Biological Process
DephosphorylationManual Assertion Based On ExperimentIBA:GO_Central
In utero embryonic developmentIEA:Ensembl
L-serine biosynthetic processManual Assertion Based On ExperimentIMP:UniProtKB
L-serine metabolic processManual Assertion Based On ExperimentIDA:UniProtKB
Response to mechanical stimulusIEA:Ensembl
Response to nutrient levelsIEA:Ensembl
Response to testosteroneIEA:Ensembl
Cellular Location
Cytoplasm, cytosol
Involvement in disease
Phosphoserine phosphatase deficiency (PSPHD):
An autosomal recessive disorder that results in pre- and postnatal growth retardation, moderate psychomotor retardation and facial features suggestive of Williams syndrome.
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Anti-PSPH antibodies

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Mouse Anti-PSPH Recombinant Antibody (3A5) (CBMAB-P3273-YC)

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Target: PSPH
Host: Mouse
Antibody Isotype: IgG2b, κ
Specificity: Human
Clone: 3A5
Application*: E, WB
Datasheet SDS

Mouse Anti-PSPH Recombinant Antibody (3C1) (CBMAB-A7154-LY)

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Target: PSPH
Host: Mouse
Antibody Isotype: IgG2a, κ
Specificity: Human
Clone: 3C1
Application*: WB, E
Datasheet SDS

Mouse Anti-PSPH Recombinant Antibody (2G9) (CBMAB-A7153-LY)

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Target: PSPH
Host: Mouse
Antibody Isotype: IgG1, κ
Specificity: Human
Clone: 2G9
Application*: WB, E
Datasheet SDS

Mouse Anti-PSPH Recombinant Antibody (CBYC-P732) (CBMAB-P3275-YC)

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Target: PSPH
Host: Mouse
Antibody Isotype: IgG1, κ
Specificity: Human, Mouse
Clone: CBYC-P732
Application*: E, P, WB
Datasheet SDS

Mouse Anti-PSPH Recombinant Antibody (3G12) (CBMAB-P3274-YC)

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Target: PSPH
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: 3G12
Application*: WB, E
Datasheet SDS
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(P): Predicted
* Abbreviations
  • AActivation
  • AGAgonist
  • APApoptosis
  • BBlocking
  • BABioassay
  • BIBioimaging
  • CImmunohistochemistry-Frozen Sections
  • CIChromatin Immunoprecipitation
  • CTCytotoxicity
  • CSCostimulation
  • DDepletion
  • DBDot Blot
  • EELISA
  • ECELISA(Cap)
  • EDELISA(Det)
  • ESELISpot
  • EMElectron Microscopy
  • FFlow Cytometry
  • FNFunction Assay
  • GSGel Supershift
  • IInhibition
  • IAEnzyme Immunoassay
  • ICImmunocytochemistry
  • IDImmunodiffusion
  • IEImmunoelectrophoresis
  • IFImmunofluorescence
  • IGImmunochromatography
  • IHImmunohistochemistry
  • IMImmunomicroscopy
  • IOImmunoassay
  • IPImmunoprecipitation
  • ISIntracellular Staining for Flow Cytometry
  • LALuminex Assay
  • LFLateral Flow Immunoassay
  • MMicroarray
  • MCMass Cytometry/CyTOF
  • MDMeDIP
  • MSElectrophoretic Mobility Shift Assay
  • NNeutralization
  • PImmunohistologyp-Paraffin Sections
  • PAPeptide Array
  • PEPeptide ELISA
  • PLProximity Ligation Assay
  • RRadioimmunoassay
  • SStimulation
  • SESandwich ELISA
  • SHIn situ hybridization
  • TCTissue Culture
  • WBWestern Blot
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