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PSPH

The protein encoded by this gene belongs to a subfamily of the phosphotransferases. This encoded enzyme is responsible for the third and last step in L-serine formation. It catalyzes magnesium-dependent hydrolysis of L-phosphoserine and is also involved in an exchange reaction between L-serine and L-phosphoserine. Deficiency of this protein is thought to be linked to Williams syndrome. [provided by RefSeq]

Full Name

phosphoserine phosphatase

Function

Catalyzes the last irreversible step in the biosynthesis of L-serine from carbohydrates, the dephosphorylation of O-phospho-L-serine to L-serine (PubMed:12213811, PubMed:15291819, PubMed:9222972, PubMed:14673469, PubMed:25080166).
L-serine can then be used in protein synthesis, to produce other amino acids, in nucleotide metabolism or in glutathione synthesis, or can be racemized to D-serine, a neuromodulator (PubMed:14673469).
May also act on O-phospho-D-serine (Probable).

Biological Process

DephosphorylationManual Assertion Based On ExperimentIBA:GO_Central
In utero embryonic developmentIEA:Ensembl
L-serine biosynthetic processManual Assertion Based On ExperimentIMP:UniProtKB
L-serine metabolic processManual Assertion Based On ExperimentIDA:UniProtKB
Response to mechanical stimulusIEA:Ensembl
Response to nutrient levelsIEA:Ensembl
Response to testosteroneIEA:Ensembl

Cellular Location

Cytoplasm, cytosol

Involvement in disease

Phosphoserine phosphatase deficiency (PSPHD):
An autosomal recessive disorder that results in pre- and postnatal growth retardation, moderate psychomotor retardation and facial features suggestive of Williams syndrome.

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Anti-PSPH antibodies

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Mouse Anti-PSPH Recombinant Antibody (3A5) (CBMAB-P3273-YC)

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Target: PSPH

Host: Mouse

Antibody Isotype: IgG2b, κ

Specificity: Human

Clone: 3A5

Application*: E, WB

Mouse Anti-PSPH Recombinant Antibody (3C1) (CBMAB-A7154-LY)

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Target: PSPH

Host: Mouse

Antibody Isotype: IgG2a, κ

Specificity: Human

Clone: 3C1

Application*: WB, E

Mouse Anti-PSPH Recombinant Antibody (2G9) (CBMAB-A7153-LY)

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Target: PSPH

Host: Mouse

Antibody Isotype: IgG1, κ

Specificity: Human

Clone: 2G9

Application*: WB, E

Mouse Anti-PSPH Recombinant Antibody (CBYC-P732) (CBMAB-P3275-YC)

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Target: PSPH

Host: Mouse

Antibody Isotype: IgG1, κ

Specificity: Human, Mouse

Clone: CBYC-P732

Application*: E, P, WB

Mouse Anti-PSPH Recombinant Antibody (3G12) (CBMAB-P3274-YC)

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Target: PSPH

Host: Mouse

Antibody Isotype: IgG1

Specificity: Human

Clone: 3G12

Application*: WB, E

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(P): Predicted

* Abbreviations

AActivation
AGAgonist
APApoptosis
BBlocking
BABioassay
BIBioimaging
CImmunohistochemistry-Frozen Sections
CIChromatin Immunoprecipitation
CTCytotoxicity
CSCostimulation
DDepletion
DBDot Blot

EELISA
ECELISA(Cap)
EDELISA(Det)
ESELISpot
EMElectron Microscopy
FFlow Cytometry
FNFunction Assay
GSGel Supershift
IInhibition
IAEnzyme Immunoassay
ICImmunocytochemistry
IDImmunodiffusion
IEImmunoelectrophoresis

IFImmunofluorescence
IGImmunochromatography
IHImmunohistochemistry
IMImmunomicroscopy
IOImmunoassay
IPImmunoprecipitation
ISIntracellular Staining for Flow Cytometry
LALuminex Assay
LFLateral Flow Immunoassay
MMicroarray
MCMass Cytometry/CyTOF
MDMeDIP

MSElectrophoretic Mobility Shift Assay
NNeutralization
PImmunohistologyp-Paraffin Sections
PAPeptide Array
PEPeptide ELISA
PLProximity Ligation Assay
RRadioimmunoassay
SStimulation
SESandwich ELISA
SHIn situ hybridization
TCTissue Culture
WBWestern Blot

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