PSRC1

PSRC1 is a proline-rich protein that is a target for regulation by the tumor suppressor protein p53. The encoded protein plays an important role in mitosis by recruiting and regulating microtubule depolymerases that destabalize microtubules.

Full Name

Proline and serine rich coiled-coil 1

Function

Required for normal progression through mitosis. Required for normal congress of chromosomes at the metaphase plate, and for normal rate of chromosomal segregation during anaphase. Plays a role in the regulation of mitotic spindle dynamics. Increases the rate of turnover of microtubules on metaphase spindles, and contributes to the generation of normal tension across sister kinetochores. Recruits KIF2A and ANKRD53 to the mitotic spindle and spindle poles. May participate in p53/TP53-regulated growth suppression.

Biological Process

Cell divisionIEA:UniProtKB-KW
Microtubule bundle formationBy SimilarityISS:BHF-UCL
Mitotic metaphase plate congressionManual Assertion Based On ExperimentIDA:UniProtKB
Negative regulation of cell growthBy SimilarityISS:BHF-UCL
Positive regulation of cyclin-dependent protein serine/threonine kinase activityBy SimilarityISS:BHF-UCL
Positive regulation of microtubule polymerizationBy SimilarityISS:BHF-UCL
Positive regulation of transcription, DNA-templatedBy SimilarityISS:BHF-UCL
Regulation of mitotic spindle organizationManual Assertion Based On ExperimentIDA:UniProtKB

Cellular Location

Cytoplasm
Cytoplasm, cytoskeleton, spindle
Cytoplasm, cytoskeleton, spindle pole
Detected at the mitotic spindle and spindle poles. Diffusely distributed throughout the cell during interphase.

PTM

Phosphorylated during mitosis.