Mouse Anti-PSRC1 Recombinant Antibody (982) (CBMAB-P3280-YC)

Name: Mouse Anti-PSRC1 Recombinant Antibody (982)
SKU: CBMAB-P3280-YC
Rating: 5 (1 reviews)

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Datasheet

SDS

Request for COA

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Basic Information

Host Animal

Mouse

Clone

982

Application

Immunogen

Recombinant protein encompassing a sequence within the center region of human PSRC1.

Specificity

Human

Antibody Isotype

IgG1

Clonality

Monoclonal

Application Notes

The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Storage

Store at 4°C short term (1-2 weeks). Aliquot and store at-20°C long term. Avoid repeated freeze/thaw cycles.

More Infomation

Target

Full Name

Proline and serine rich coiled-coil 1

Introduction

PSRC1 is a proline-rich protein that is a target for regulation by the tumor suppressor protein p53. The encoded protein plays an important role in mitosis by recruiting and regulating microtubule depolymerases that destabalize microtubules.

Entrez Gene ID

84722

UniProt ID

Q6PGN9

Alternative Names

FP3214; DDA3

Function

Required for normal progression through mitosis. Required for normal congress of chromosomes at the metaphase plate, and for normal rate of chromosomal segregation during anaphase. Plays a role in the regulation of mitotic spindle dynamics. Increases the rate of turnover of microtubules on metaphase spindles, and contributes to the generation of normal tension across sister kinetochores. Recruits KIF2A and ANKRD53 to the mitotic spindle and spindle poles. May participate in p53/TP53-regulated growth suppression.

Biological Process

Cell divisionIEA:UniProtKB-KW
Microtubule bundle formationBy SimilarityISS:BHF-UCL
Mitotic metaphase plate congressionManual Assertion Based On ExperimentIDA:UniProtKB
Negative regulation of cell growthBy SimilarityISS:BHF-UCL
Positive regulation of cyclin-dependent protein serine/threonine kinase activityBy SimilarityISS:BHF-UCL
Positive regulation of microtubule polymerizationBy SimilarityISS:BHF-UCL
Positive regulation of transcription, DNA-templatedBy SimilarityISS:BHF-UCL
Regulation of mitotic spindle organizationManual Assertion Based On ExperimentIDA:UniProtKB

Cellular Location

Cytoplasm
Cytoplasm, cytoskeleton, spindle
Cytoplasm, cytoskeleton, spindle pole
Detected at the mitotic spindle and spindle poles. Diffusely distributed throughout the cell during interphase.

PTM

Phosphorylated during mitosis.

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Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme-Linked Immunospot (ELISpot)
Proteogenomics
Other Protocols

Related Products

Mouse Anti-PSRC1 Recombinant Antibody (615) (CAT#: CBMAB-P3279-YC)

Isotype control

For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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