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Mouse Anti-PSRC1 Recombinant Antibody (982) (CBMAB-P3280-YC)

Provided herein is a Mouse monoclonal antibody against Human Proline and serine rich coiled-coil 1. The antibody can be used for immunoassay techniques, such as WB.
See all PSRC1 antibodies

Summary

Host Animal
Mouse
Specificity
Human
Clone
982
Antibody Isotype
IgG1
Application
WB

Basic Information

Immunogen
Recombinant protein encompassing a sequence within the center region of human PSRC1.
Specificity
Human
Antibody Isotype
IgG1
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Storage
Store at 4°C short term (1-2 weeks). Aliquot and store at-20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
Proline and serine rich coiled-coil 1
Introduction
PSRC1 is a proline-rich protein that is a target for regulation by the tumor suppressor protein p53. The encoded protein plays an important role in mitosis by recruiting and regulating microtubule depolymerases that destabalize microtubules.
Entrez Gene ID
84722
UniProt ID
Q6PGN9
Alternative Names
FP3214; DDA3
Function
Required for normal progression through mitosis. Required for normal congress of chromosomes at the metaphase plate, and for normal rate of chromosomal segregation during anaphase. Plays a role in the regulation of mitotic spindle dynamics. Increases the rate of turnover of microtubules on metaphase spindles, and contributes to the generation of normal tension across sister kinetochores. Recruits KIF2A and ANKRD53 to the mitotic spindle and spindle poles. May participate in p53/TP53-regulated growth suppression.
Biological Process
Cell divisionIEA:UniProtKB-KW
Microtubule bundle formationBy SimilarityISS:BHF-UCL
Mitotic metaphase plate congressionManual Assertion Based On ExperimentIDA:UniProtKB
Negative regulation of cell growthBy SimilarityISS:BHF-UCL
Positive regulation of cyclin-dependent protein serine/threonine kinase activityBy SimilarityISS:BHF-UCL
Positive regulation of microtubule polymerizationBy SimilarityISS:BHF-UCL
Positive regulation of transcription, DNA-templatedBy SimilarityISS:BHF-UCL
Regulation of mitotic spindle organizationManual Assertion Based On ExperimentIDA:UniProtKB
Cellular Location
Cytoplasm
Cytoplasm, cytoskeleton, spindle
Cytoplasm, cytoskeleton, spindle pole
Detected at the mitotic spindle and spindle poles. Diffusely distributed throughout the cell during interphase.
PTM
Phosphorylated during mitosis.
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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