PTGFR

Ptgfr has biased expression in ovary adult (RPKM 14.0), heart adult (RPKM 2.7) and 5 other tissues.

Full Name

Prostaglandin F receptor

Function

Receptor for prostaglandin F2-alpha (PGF2-alpha). The activity of this receptor is mediated by G proteins which activate a phosphatidylinositol-calcium second messenger system. Initiates luteolysis in the corpus luteum (By similarity).
Isoforms 2 to 7 do not bind PGF2-alpha but are proposed to modulate signaling by participating in variant receptor complexes; heterodimers between isoform 1 and isoform 5 are proposed to be a receptor for prostamides including the synthetic analog bimatoprost.

Biological Process

Adenylate cyclase-activating G protein-coupled receptor signaling pathwayManual Assertion Based On ExperimentIBA:GO_Central
Calcium-mediated signaling using intracellular calcium sourceManual Assertion Based On ExperimentIDA:UniProtKB
Cellular response to prostaglandin D stimulusManual Assertion Based On ExperimentIMP:UniProtKB
G protein-coupled receptor signaling pathwayManual Assertion Based On ExperimentTAS:ProtInc
Inflammatory responseManual Assertion Based On ExperimentIBA:GO_Central
Negative regulation of apoptotic processIEA:Ensembl
ParturitionManual Assertion Based On ExperimentTAS:ProtInc
Positive regulation of cell population proliferationManual Assertion Based On ExperimentIMP:UniProtKB
Positive regulation of cytosolic calcium ion concentrationManual Assertion Based On ExperimentIBA:GO_Central
Positive regulation of gene expressionIEA:Ensembl
Response to estradiolIEA:Ensembl
Response to lipopolysaccharideIEA:Ensembl

Cellular Location

Cell membrane

Topology

Extracellular: 1-31
Helical: 32-54
Cytoplasmic: 55-69
Helical: 70-90
Extracellular: 91-109
Helical: 110-131
Cytoplasmic: 132-152
Helical: 153-175
Extracellular: 176-198
Helical: 199-224
Cytoplasmic: 225-250
Helical: 251-267
Extracellular: 268-285
Helical: 286-307
Cytoplasmic: 308-359