PTH2R

PTH2R is a member of the G-protein coupled receptor 2 family. This protein is a receptor for parathyroid hormone (PTH). This receptor is more selective in ligand recognition and has a more specific tissue distribution compared to parathyroid hormone receptor 1 (PTHR1). It is activated only by PTH and not by parathyroid hormone-like hormone (PTHLH) and is particularly abundant in brain and pancreas.

Full Name

Parathyroid hormone 2 receptor

Function

This is a specific receptor for parathyroid hormone. The activity of this receptor is mediated by G proteins which activate adenylyl cyclase. PTH2R may be responsible for PTH effects in a number of physiological systems. It may play a significant role in pancreatic function. PTH2R presence in neurons indicates that it may function as a neurotransmitter receptor (By similarity).

Biological Process

Adenylate cyclase-modulating G protein-coupled receptor signaling pathwayManual Assertion Based On ExperimentIBA:GO_Central
Cell surface receptor signaling pathwayIEA:InterPro
G protein-coupled receptor signaling pathwayManual Assertion Based On ExperimentTAS:ProtInc
Positive regulation of cold-induced thermogenesisBy SimilarityISS:YuBioLab

Cellular Location

Cell membrane

Topology

Extracellular: 27-145
Helical: 146-169
Cytoplasmic: 170-176
Helical: 177-196
Extracellular: 197-237
Helical: 238-260
Cytoplasmic: 261-275
Helical: 276-297
Extracellular: 298-316
Helical: 317-337
Cytoplasmic: 338-364
Helical: 365-383
Extracellular: 384-394
Helical: 395-417
Cytoplasmic: 418-550