PTH2R

PTH2R is a member of the G-protein coupled receptor 2 family. This protein is a receptor for parathyroid hormone (PTH). This receptor is more selective in ligand recognition and has a more specific tissue distribution compared to parathyroid hormone receptor 1 (PTHR1). It is activated only by PTH and not by parathyroid hormone-like hormone (PTHLH) and is particularly abundant in brain and pancreas.

Full Name

Parathyroid hormone 2 receptor

Function

This is a specific receptor for parathyroid hormone. The activity of this receptor is mediated by G proteins which activate adenylyl cyclase. PTH2R may be responsible for PTH effects in a number of physiological systems. It may play a significant role in pancreatic function. PTH2R presence in neurons indicates that it may function as a neurotransmitter receptor (By similarity).

Biological Process

Adenylate cyclase-modulating G protein-coupled receptor signaling pathwayManual Assertion Based On ExperimentIBA:GO_Central
Cell surface receptor signaling pathwayIEA:InterPro
G protein-coupled receptor signaling pathwayManual Assertion Based On ExperimentTAS:ProtInc
Positive regulation of cold-induced thermogenesisBy SimilarityISS:YuBioLab

Cellular Location

Cell membrane

Topology

Extracellular: 27-145
Helical: 146-169
Cytoplasmic: 170-176
Helical: 177-196
Extracellular: 197-237
Helical: 238-260
Cytoplasmic: 261-275
Helical: 276-297
Extracellular: 298-316
Helical: 317-337
Cytoplasmic: 338-364
Helical: 365-383
Extracellular: 384-394
Helical: 395-417
Cytoplasmic: 418-550

Anti-PTH2R antibodies

Mouse Anti-PTH2R Recombinant Antibody (CBYC-P763) (CBMAB-P3363-YC)

Datasheet

SDS

Target: PTH2R

Host: Mouse

Antibody Isotype: IgG

Specificity: Chicken

Clone: CBYC-P763

Application*: E, WB

Mouse Anti-PTH2R Recombinant Antibody (CBYC-P762) (CBMAB-P3362-YC)

Datasheet

SDS

Target: PTH2R

Host: Mouse

Antibody Isotype: IgG

Specificity: Rat

Clone: CBYC-P762

Application*: WB, IC, P, C, E

Mouse Anti-PTH2R Recombinant Antibody (CBYC-P761) (CBMAB-P3361-YC)

Datasheet

SDS

Target: PTH2R

Host: Mouse

Antibody Isotype: IgG

Specificity: Human

Clone: CBYC-P761

Application*: WB, IC, P, C, E

For Research Use Only. Not For Clinical Use.

(P): Predicted

* Abbreviations

IFImmunofluorescence

IHImmunohistochemistry

IPImmunoprecipitation

WBWestern Blot

EELISA

MMicroarray

CIChromatin Immunoprecipitation

FFlow Cytometry

FNFunction Assay

IDImmunodiffusion

RRadioimmunoassay

TCTissue Culture

GSGel Supershift

NNeutralization

BBlocking

AActivation

IInhibition

DDepletion

ESELISpot

DBDot Blot

MCMass Cytometry/CyTOF

CTCytotoxicity

SStimulation

AGAgonist

APApoptosis

IMImmunomicroscopy

BABioassay

CSCostimulation

EMElectron Microscopy

IEImmunoelectrophoresis

PAPeptide Array

ICImmunocytochemistry

PEPeptide ELISA

MDMeDIP

SHIn situ hybridization

IAEnzyme Immunoassay

SEsandwich ELISA

PLProximity Ligation Assay

ECELISA(Cap)

EDELISA(Det)

BIBioimaging

IOImmunoassay

LFLateral Flow Immunoassay

LALuminex Assay

CImmunohistochemistry-Frozen Sections

PImmunohistologyp-Paraffin Sections

ISIntracellular Staining for Flow Cytometry

MSElectrophoretic Mobility Shift Assay

RIRNA Binding Protein Immunoprecipitation (RIP)