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Mouse Anti-PTH2R Recombinant Antibody (CBYC-P762) (CBMAB-P3362-YC)

Provided herein is a Mouse monoclonal antibody against Rat Parathyroid hormone 2 receptor. The antibody can be used for immunoassay techniques, such as WB, ICC, IHC-P, IHC-Fr, ELISA.
See all PTH2R antibodies

Summary

Host Animal
Mouse
Specificity
Rat
Clone
CBYC-P762
Antibody Isotype
IgG
Application
WB, ICC, IHC-P, IHC-Fr, ELISA

Basic Information

Immunogen
Parathyroid Hormone Receptor 2
Specificity
Rat
Antibody Isotype
IgG
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
PBS, pH 7.4, 0.02% sodium azide, 50% glycerol
Storage
Store at 4°C short term (1-2 weeks). Aliquot and store at-20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
Parathyroid hormone 2 receptor
Introduction
PTH2R is a member of the G-protein coupled receptor 2 family. This protein is a receptor for parathyroid hormone (PTH). This receptor is more selective in ligand recognition and has a more specific tissue distribution compared to parathyroid hormone receptor 1 (PTHR1). It is activated only by PTH and not by parathyroid hormone-like hormone (PTHLH) and is particularly abundant in brain and pancreas.
Entrez Gene ID
UniProt ID
Alternative Names
PTHR2
Function
This is a specific receptor for parathyroid hormone. The activity of this receptor is mediated by G proteins which activate adenylyl cyclase. PTH2R may be responsible for PTH effects in a number of physiological systems. It may play a significant role in pancreatic function. PTH2R presence in neurons indicates that it may function as a neurotransmitter receptor (By similarity).
Biological Process
Adenylate cyclase-modulating G protein-coupled receptor signaling pathwayManual Assertion Based On ExperimentIBA:GO_Central
Cell surface receptor signaling pathwayIEA:InterPro
G protein-coupled receptor signaling pathwayManual Assertion Based On ExperimentTAS:ProtInc
Positive regulation of cold-induced thermogenesisBy SimilarityISS:YuBioLab
Cellular Location
Cell membrane
Topology
Extracellular: 27-145
Helical: 146-169
Cytoplasmic: 170-176
Helical: 177-196
Extracellular: 197-237
Helical: 238-260
Cytoplasmic: 261-275
Helical: 276-297
Extracellular: 298-316
Helical: 317-337
Cytoplasmic: 338-364
Helical: 365-383
Extracellular: 384-394
Helical: 395-417
Cytoplasmic: 418-550
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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