PTTG1IP

The encoded protein, which directly binds to pituitary tumor-transforming gene 1 protein (PTTG1), facilitates the nuclear translocation of PTTG1 and potentiates the transcriptional activation of basic fibroblast growth factor by PTTG1. The gene product localizes to both the cytoplasm and nucleus. Its NLS is required for its own nuclear localization, the nuclear localization of PTTG1, and its interaction with PTTG1. [provided by RefSeq]

Full Name

pituitary tumor-transforming 1 interacting protein

Function

May facilitate PTTG1 nuclear translocation.

Biological Process

Negative regulation of DNA damage response, signal transduction by p53 class mediatorManual Assertion Based On ExperimentIMP:MGI
Negative regulation of intrinsic apoptotic signaling pathway by p53 class mediatorManual Assertion Based On ExperimentIMP:MGI
Positive regulation of protein ubiquitinationManual Assertion Based On ExperimentIDA:MGI
Protein import into nucleusManual Assertion Based On ExperimentIDA:UniProtKB

Cellular Location

Membrane
Cytoplasm
Nucleus
According to PubMed:10781616, it is found in the cytoplasm and the nucleus.

Topology

Extracellular: 33-96
Helical: 97-117
Cytoplasmic: 118-180