RAD23A

The protein encoded by this gene is one of two human homologs of Saccharomyces cerevisiae Rad23, a protein involved in nucleotide excision repair. Proteins in this family have a modular domain structure consisting of an ubiquitin-like domain (UbL), ubiquitin-associated domain 1 (UbA1), XPC-binding domain and UbA2. The protein encoded by this gene plays an important role in nucleotide excision repair and also in delivery of polyubiquitinated proteins to the proteasome. Alternative splicing results in multiple transcript variants encoding multiple isoforms. [provided by RefSeq, Jun 2012]
Full Name
RAD23 Homolog A, Nucleotide Excision Repair Protein
Function
Multiubiquitin chain receptor involved in modulation of proteasomal degradation. Binds to 'Lys-48'-linked polyubiquitin chains in a length-dependent manner and with a lower affinity to 'Lys-63'-linked polyubiquitin chains. Proposed to be capable to bind simultaneously to the 26S proteasome and to polyubiquitinated substrates and to deliver ubiquitinated proteins to the proteasome.
Involved in nucleotide excision repair and is thought to be functional equivalent for RAD23B in global genome nucleotide excision repair (GG-NER) by association with XPC. In vitro, the XPC:RAD23A dimer has NER activity. Can stabilize XPC.
(Microbial infection) Involved in Vpr-dependent replication of HIV-1 in non-proliferating cells and primary macrophages. Required for the association of HIV-1 Vpr with the host proteasome.
Biological Process
Biological Process nucleotide-excision repairManual Assertion Based On ExperimentIDA:UniProtKB
Biological Process positive regulation of cell cycleManual Assertion Based On ExperimentIMP:CAFA
Biological Process positive regulation of proteasomal ubiquitin-dependent protein catabolic processManual Assertion Based On ExperimentIMP:CAFA
Biological Process positive regulation of viral genome replicationManual Assertion Based On ExperimentIMP:UniProtKB
Biological Process proteasome-mediated ubiquitin-dependent protein catabolic processManual Assertion Based On ExperimentIBA:GO_Central
Biological Process protein destabilizationManual Assertion Based On ExperimentIMP:CAFA
Biological Process regulation of proteasomal ubiquitin-dependent protein catabolic processManual Assertion Based On ExperimentIDA:UniProtKB
Cellular Location
Nucleus
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Anti-RAD23A antibodies

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Rabbit Anti-RAD23A Recombinant Antibody (D7U7Z) (CBMAB-CP2184-LY)

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Target: RAD23A
Host: Rabbit
Antibody Isotype: IgG
Specificity: Human, Mouse, Rat, Monkey
Clone: D7U7Z
Application*: WB, IP
Datasheet SDS

Mouse Anti-RAD23A Recombinant Antibody (CBT3047) (V2LY-0625-LY400)

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Target: RAD23A
Host: Mouse
Antibody Isotype: IgG2b
Specificity: Human
Clone: CBT3047
Application*: IH, F
Datasheet SDS

Mouse Anti-RAD23A Recombinant Antibody (CBT2907) (V2LY-0625-LY399)

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Target: RAD23A
Host: Mouse
Antibody Isotype: IgG2b
Specificity: Human
Clone: CBT2907
Application*: WB
Datasheet SDS

Mouse Anti-RAD23A Recombinant Antibody (CBFYH-3651) (CBMAB-H4211-FY)

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Target: RAD23A
Host: Mouse
Antibody Isotype: IgG2a
Specificity: Human
Clone: CBFYH-3651
Application*: WB, P, F, IF
Datasheet SDS

Rabbit Anti-RAD23A Recombinant Antibody (CBCNR-116) (CBMAB-R1060-CN)

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Target: RAD23A
Host: Rabbit
Antibody Isotype: IgG
Specificity: Mouse, Rat, Human
Clone: CBCNR-116
Application*: WB, F
Datasheet SDS

Mouse Anti-RAD23A Recombinant Antibody (3C12) (CBMAB-R1058-CN)

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Target: RAD23A
Host: Mouse
Antibody Isotype: IgG2a, κ
Specificity: Human
Clone: 3C12
Application*: WB, E
Datasheet SDS

Mouse Anti-RAD23A Recombinant Antibody (1E4D6) (CBMAB-R1057-CN)

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Target: RAD23A
Host: Mouse
Antibody Isotype: IgG2b
Specificity: Human
Clone: 1E4D6
Application*: E, WB
Datasheet SDS

Mouse Anti-RAD23A (AA 1-363) Recombinant Antibody (3E3F4) (CBMAB-H0480-FY)

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Target: RAD23A
Host: Mouse
Specificity: Human
Clone: 3E3F4
Application*: WB, F, E, IH, P, IC, MC
Datasheet SDS

Mouse Anti-RAD23A (AA 1-363) Monoclonal Antibody (CBFYH-3301) (CBMAB-H0389-FY)

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Target: RAD23A
Host: Mouse
Specificity: Human
Clone: CBFYH-3301
Application*: WB, F, E, IH, IC, MC
Datasheet SDS
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(P): Predicted
* Abbreviations
  • AActivation
  • AGAgonist
  • APApoptosis
  • BBlocking
  • BABioassay
  • BIBioimaging
  • CImmunohistochemistry-Frozen Sections
  • CIChromatin Immunoprecipitation
  • CTCytotoxicity
  • CSCostimulation
  • DDepletion
  • DBDot Blot
  • EELISA
  • ECELISA(Cap)
  • EDELISA(Det)
  • ESELISpot
  • EMElectron Microscopy
  • FFlow Cytometry
  • FNFunction Assay
  • GSGel Supershift
  • IInhibition
  • IAEnzyme Immunoassay
  • ICImmunocytochemistry
  • IDImmunodiffusion
  • IEImmunoelectrophoresis
  • IFImmunofluorescence
  • IGImmunochromatography
  • IHImmunohistochemistry
  • IMImmunomicroscopy
  • IOImmunoassay
  • IPImmunoprecipitation
  • ISIntracellular Staining for Flow Cytometry
  • LALuminex Assay
  • LFLateral Flow Immunoassay
  • MMicroarray
  • MCMass Cytometry/CyTOF
  • MDMeDIP
  • MSElectrophoretic Mobility Shift Assay
  • NNeutralization
  • PImmunohistologyp-Paraffin Sections
  • PAPeptide Array
  • PEPeptide ELISA
  • PLProximity Ligation Assay
  • RRadioimmunoassay
  • SStimulation
  • SESandwich ELISA
  • SHIn situ hybridization
  • TCTissue Culture
  • WBWestern Blot
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