RCOR1

This gene encodes a protein that is well-conserved, downregulated at birth, and with a specific role in determining neural cell differentiation. The encoded protein binds to the C-terminal domain of REST (repressor element-1 silencing transcription factor). [provided by RefSeq, Aug 2011]

Full Name

REST Corepressor 1

Function

Essential component of the BHC complex, a corepressor complex that represses transcription of neuron-specific genes in non-neuronal cells. The BHC complex is recruited at RE1/NRSE sites by REST and acts by deacetylating and demethylating specific sites on histones, thereby acting as a chromatin modifier. In the BHC complex, it serves as a molecular beacon for the recruitment of molecular machinery, including MeCP2 and SUV39H1, that imposes silencing across a chromosomal interval. Plays a central role in demethylation of Lys-4 of histone H3 by promoting demethylase activity of KDM1A on core histones and nucleosomal substrates. It also protects KDM1A from the proteasome. Component of a RCOR/GFI/KDM1A/HDAC complex that suppresses, via histone deacetylase (HDAC) recruitment, a number of genes implicated in multilineage blood cell development and controls hematopoietic differentiation.

Biological Process

Biological Process chromatin organizationIEA:UniProtKB-KW
Biological Process erythrocyte differentiationIEA:Ensembl
Biological Process histone deacetylationManual Assertion Based On ExperimentIBA:GO_Central
Biological Process histone H4 deacetylationManual Assertion Based On ExperimentIDA:UniProtKB
Biological Process negative regulation of gene expressionIEA:Ensembl
Biological Process negative regulation of transcription, DNA-templatedManual Assertion Based On ExperimentIDA:UniProtKB
Biological Process positive regulation of megakaryocyte differentiationIEA:Ensembl
Biological Process regulation of transcription by RNA polymerase IIManual Assertion Based On ExperimentIBA:GO_Central

Cellular Location

Nucleus
Upon infection by HSV-1, it is partially translocated into the cytoplasm in an HSV-1-dependent manner.

PTM

Phosphorylated by HSV-1 protein kinases in case of infection.