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Mouse Anti-RCOR1 Recombinant Antibody (S72-8) (CBMAB-R1946-CN)

This product is a Mouse antibody that recognizes RCOR1. The antibody S72-8 can be used for immunoassay techniques such as: WB, IHC, ICC.
See all RCOR1 antibodies

Summary

Host Animal
Mouse
Specificity
Human, Mouse, Rat
Clone
S72-8
Antibody Isotype
IgG1
Application
WB, IHC, ICC

Basic Information

Immunogen
Fusion protein aa. 109-293 of human Co-Rest
Specificity
Human, Mouse, Rat
Antibody Isotype
IgG1
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Buffer
PBS, pH 7.4, 50% Glycerol
Preservative
0.09% Sodium azide
Concentration
1 mg/mL

Target

Full Name
REST Corepressor 1
Introduction
This gene encodes a protein that is well-conserved, downregulated at birth, and with a specific role in determining neural cell differentiation. The encoded protein binds to the C-terminal domain of REST (repressor element-1 silencing transcription factor). [provided by RefSeq, Aug 2011]
Entrez Gene ID
Human23186
Mouse217864
Rat102554884
UniProt ID
HumanQ9UKL0
MouseQ8CFE3
RatP49743
Alternative Names
REST Corepressor 1; RCOR; REST Corepressor; Protein CoREST; KIAA0071; COREST;
Function
Essential component of the BHC complex, a corepressor complex that represses transcription of neuron-specific genes in non-neuronal cells. The BHC complex is recruited at RE1/NRSE sites by REST and acts by deacetylating and demethylating specific sites on histones, thereby acting as a chromatin modifier. In the BHC complex, it serves as a molecular beacon for the recruitment of molecular machinery, including MeCP2 and SUV39H1, that imposes silencing across a chromosomal interval. Plays a central role in demethylation of Lys-4 of histone H3 by promoting demethylase activity of KDM1A on core histones and nucleosomal substrates. It also protects KDM1A from the proteasome. Component of a RCOR/GFI/KDM1A/HDAC complex that suppresses, via histone deacetylase (HDAC) recruitment, a number of genes implicated in multilineage blood cell development and controls hematopoietic differentiation.
Biological Process
Biological Process chromatin organizationIEA:UniProtKB-KW
Biological Process erythrocyte differentiationIEA:Ensembl
Biological Process histone deacetylationManual Assertion Based On ExperimentIBA:GO_Central
Biological Process histone H4 deacetylationManual Assertion Based On ExperimentIDA:UniProtKB
Biological Process negative regulation of gene expressionIEA:Ensembl
Biological Process negative regulation of transcription, DNA-templatedManual Assertion Based On ExperimentIDA:UniProtKB
Biological Process positive regulation of megakaryocyte differentiationIEA:Ensembl
Biological Process regulation of transcription by RNA polymerase IIManual Assertion Based On ExperimentIBA:GO_Central
Cellular Location
Nucleus
Upon infection by HSV-1, it is partially translocated into the cytoplasm in an HSV-1-dependent manner.
PTM
Phosphorylated by HSV-1 protein kinases in case of infection.
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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