REXO2

Nucleases are components of DNA and RNA metabolism that carry out functions in DNA repair, replication, and recombination and in RNA processing and degradation. SFN is a homolog of Orn, a 3-prime-to-5-prime exoribonuclease of E. coli that attacks the free 3-prime hydroxyl group on single-stranded RNA, releasing 5-prime mononucleotides in a sequential manner.[supplied by OMIM

Full Name

REX2, RNA exonuclease 2 homolog (S. cerevisiae)

Function

3'-to-5'exoribonuclease that preferentially degrades DNA and RNA oligonucleotides composed of only two nucleotides (PubMed:31588022, PubMed:30926754, PubMed:32365187, PubMed:23741365).
Binds and degrades longer oligonucleotides with a lower affinity (PubMed:31588022, PubMed:30926754, PubMed:32365187).
Plays dual roles in mitochondria, scavenging nanoRNAs (small RNA oligonucleotides of <5 nucleotides) that are produced by the degradosome and clearing short RNAs that are generated by RNA processing (PubMed:31588022, PubMed:30926754, PubMed:32365187).
Essential for correct initiation of mitochondrial transcription, degrading mitochondrial RNA dinucleotides to prevent RNA-primed transcription at non-canonical sites in the mitochondrial genome (PubMed:31588022).
Essential for embryonic development (By similarity).
Isoform 3
3'-to-5'exoribonuclease that preferentially degrades DNA and RNA oligonucleotides composed of only two nucleotides.

Biological Process

Biological Process nucleobase-containing compound metabolic processManual Assertion Based On ExperimentIDA:MGI
Biological Process nucleotide metabolic processManual Assertion Based On ExperimentTAS:ProtInc

Cellular Location

Mitochondrion intermembrane space
Mitochondrion matrix
Mitochondrion
Cytoplasm
Nucleus
Isoform 3
Cytoplasm
Nucleus