Mouse Anti-REXO2 Recombinant Antibody (2B5) (CBMAB-R2303-CN)

Name: Mouse Anti-REXO2 Recombinant Antibody (2B5)
SKU: CBMAB-R2303-CN
Rating: 5 (1 reviews)

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Datasheet

SDS

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Basic Information

Host Animal

Mouse

Clone

2B5

Application

ELISA, WB

Immunogen

REXO2 (NP_056338, aa. 101-210) partial recombinant protein with GST tag

Specificity

Human

Antibody Isotype

IgG2b, κ

Application Notes

The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Buffer

PBS, pH 7.4

Preservative

No preservatives

Concentration

0.2-1.0 mg/mL

More Infomation

Target

Full Name

REX2, RNA exonuclease 2 homolog (S. cerevisiae)

Introduction

This gene encodes a 3'-to-5' exonuclease specific for small (primarily 5 nucleotides or less in length) single-stranded RNA and DNA oligomers. This protein may have a role in DNA repair, replication, and recombination, and in RNA processing and degradation. It may also be involved in resistance of human cells to UV-C-induced cell death through its role in the DNA repair process. [provided by RefSeq, Nov 2011]

Entrez Gene ID

25996

UniProt ID

Q9Y3B8

Alternative Names

RNA Exonuclease 2; RNA Exonuclease 2 Homolog; Small Fragment Nuclease; SFN; REX2, RNA Exonuclease 2 Homolog (S. Cerevisiae); Oligoribonuclease, Mitochondrial; REX2, RNA Exonuclease 2 Homolog;

Function

3'-to-5'exoribonuclease that preferentially degrades DNA and RNA oligonucleotides composed of only two nucleotides (PubMed:31588022, PubMed:30926754, PubMed:32365187, PubMed:23741365).
Binds and degrades longer oligonucleotides with a lower affinity (PubMed:31588022, PubMed:30926754, PubMed:32365187).
Plays dual roles in mitochondria, scavenging nanoRNAs (small RNA oligonucleotides of <5 nucleotides) that are produced by the degradosome and clearing short RNAs that are generated by RNA processing (PubMed:31588022, PubMed:30926754, PubMed:32365187).
Essential for correct initiation of mitochondrial transcription, degrading mitochondrial RNA dinucleotides to prevent RNA-primed transcription at non-canonical sites in the mitochondrial genome (PubMed:31588022).
Essential for embryonic development (By similarity).
Isoform 3
3'-to-5'exoribonuclease that preferentially degrades DNA and RNA oligonucleotides composed of only two nucleotides.

Biological Process

Biological Process nucleobase-containing compound metabolic processManual Assertion Based On ExperimentIDA:MGI
Biological Process nucleotide metabolic processManual Assertion Based On ExperimentTAS:ProtInc

Cellular Location

Mitochondrion intermembrane space
Mitochondrion matrix
Mitochondrion
Cytoplasm
Nucleus
Isoform 3
Cytoplasm
Nucleus

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Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme-Linked Immunospot (ELISpot)
Proteogenomics
Other Protocols

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Isotype control

For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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