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Mouse Anti-REXO2 Recombinant Antibody (15B58) (CBMAB-R2301-CN)

This product is a Mouse antibody that recognizes REXO2. The antibody 15B58 can be used for immunoassay techniques such as: ELISA, WB.
See all REXO2 antibodies

Summary

Host Animal
Mouse
Specificity
Human
Clone
15B58
Application
ELISA, WB

Basic Information

Immunogen
Recombinant protein corresponding to aa. 26-237 from human REXO 2 expressed in E. coli
Specificity
Human
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Buffer
PBS, pH 7.4, 10% Glycerol
Preservative
0.02% Sodium azide
Concentration
1 mg/mL

Target

Full Name
REX2, RNA exonuclease 2 homolog (S. cerevisiae)
Introduction
This gene encodes a 3'-to-5' exonuclease specific for small (primarily 5 nucleotides or less in length) single-stranded RNA and DNA oligomers. This protein may have a role in DNA repair, replication, and recombination, and in RNA processing and degradation. It may also be involved in resistance of human cells to UV-C-induced cell death through its role in the DNA repair process. [provided by RefSeq, Nov 2011]
Entrez Gene ID
25996
UniProt ID
Q9Y3B8
Alternative Names
RNA Exonuclease 2; RNA Exonuclease 2 Homolog; Small Fragment Nuclease; SFN; REX2, RNA Exonuclease 2 Homolog (S. Cerevisiae); Oligoribonuclease, Mitochondrial; REX2, RNA Exonuclease 2 Homolog;
Function
3'-to-5'exoribonuclease that preferentially degrades DNA and RNA oligonucleotides composed of only two nucleotides (PubMed:31588022, PubMed:30926754, PubMed:32365187, PubMed:23741365).
Binds and degrades longer oligonucleotides with a lower affinity (PubMed:31588022, PubMed:30926754, PubMed:32365187).
Plays dual roles in mitochondria, scavenging nanoRNAs (small RNA oligonucleotides of <5 nucleotides) that are produced by the degradosome and clearing short RNAs that are generated by RNA processing (PubMed:31588022, PubMed:30926754, PubMed:32365187).
Essential for correct initiation of mitochondrial transcription, degrading mitochondrial RNA dinucleotides to prevent RNA-primed transcription at non-canonical sites in the mitochondrial genome (PubMed:31588022).
Essential for embryonic development (By similarity).
Isoform 3
3'-to-5'exoribonuclease that preferentially degrades DNA and RNA oligonucleotides composed of only two nucleotides.
Biological Process
Biological Process nucleobase-containing compound metabolic processManual Assertion Based On ExperimentIDA:MGI
Biological Process nucleotide metabolic processManual Assertion Based On ExperimentTAS:ProtInc
Cellular Location
Mitochondrion intermembrane space
Mitochondrion matrix
Mitochondrion
Cytoplasm
Nucleus
Isoform 3
Cytoplasm
Nucleus
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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