RHOT1

RHOT1 (Ras Homolog Family Member T1) is a Protein Coding gene. Among its related pathways are Mitophagy - animal and Metabolism of proteins. Gene Ontology (GO) annotations related to this gene include calcium ion binding and GTPase activity. An important paralog of this gene is RHOT2.
Full Name
ras homolog gene family, member T1
Function
Mitochondrial GTPase involved in mitochondrial trafficking (PubMed:12482879, PubMed:16630562, PubMed:22396657).
Probably involved in control of anterograde transport of mitochondria and their subcellular distribution (PubMed:12482879, PubMed:16630562, PubMed:22396657).
Promotes mitochondrial fission during high calcium conditions (PubMed:27716788).
Biological Process
Biological Process cellular homeostasisManual Assertion Based On ExperimentIMP:UniProtKB
Biological Process mitochondrial outer membrane permeabilizationManual Assertion Based On ExperimentIMP:UniProtKB
Biological Process mitochondrion organizationManual Assertion Based On ExperimentIBA:GO_Central
Biological Process mitochondrion transport along microtubuleManual Assertion Based On ExperimentIMP:UniProtKB
Biological Process regulation of mitochondrion organizationManual Assertion Based On ExperimentIMP:UniProtKB
Biological Process small GTPase mediated signal transductionIEA:InterPro
Cellular Location
Mitochondrion outer membrane
Colocalizes with MGARP and RHOT2 at the mitochondria.
Topology
Cytoplasmic: 1-592
Helical: 593-615
Mitochondrial intermembrane: 616-618
PTM
Ubiquitinated by PRKN during mitophagy, leading to its degradation and enhancement of mitophagy (PubMed:22396657, PubMed:24896179).
Deubiquitinated by USP30 (PubMed:24896179).
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Anti-RHOT1 antibodies

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Mouse Anti-RHOT1 Recombinant Antibody (CL1095) (CBMAB-R2610-CN)

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Target: RHOT1
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CL1095
Application*: IH, P
Datasheet SDS

Mouse Anti-RHOT1 Recombinant Antibody (CBCNR-490) (CBMAB-R2608-CN)

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Target: RHOT1
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBCNR-490
Application*: WB, F
Datasheet SDS

Mouse Anti-RHOT1 Recombinant Antibody (A-8) (CBMAB-R2607-CN)

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Target: RHOT1
Host: Mouse
Specificity: Human
Clone: A-8
Application*: WB, IP, IF, E
Datasheet SDS

Mouse Anti-RHOT1 Recombinant Antibody (4H4) (CBMAB-R2606-CN)

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Target: RHOT1
Host: Mouse
Antibody Isotype: IgG1, κ
Specificity: Human
Clone: 4H4
Application*: E, WB
Datasheet SDS

Mouse Anti-RHOT1 Recombinant Antibody (CL1083) (CBMAB-1770-CN)

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Target: RHOT1
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human, Mouse, Rat
Clone: CL1083
Application*: WB, IH, P
Datasheet SDS

Mouse Anti-RHOT1 Recombinant Antibody (1A12) (CBMAB-1769-CN)

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Target: RHOT1
Host: Mouse
Antibody Isotype: IgG1, κ
Specificity: Human
Clone: 1A12
Application*: WB, E, IF
Datasheet SDS
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(P): Predicted
* Abbreviations
  • AActivation
  • AGAgonist
  • APApoptosis
  • BBlocking
  • BABioassay
  • BIBioimaging
  • CImmunohistochemistry-Frozen Sections
  • CIChromatin Immunoprecipitation
  • CTCytotoxicity
  • CSCostimulation
  • DDepletion
  • DBDot Blot
  • EELISA
  • ECELISA(Cap)
  • EDELISA(Det)
  • ESELISpot
  • EMElectron Microscopy
  • FFlow Cytometry
  • FNFunction Assay
  • GSGel Supershift
  • IInhibition
  • IAEnzyme Immunoassay
  • ICImmunocytochemistry
  • IDImmunodiffusion
  • IEImmunoelectrophoresis
  • IFImmunofluorescence
  • IGImmunochromatography
  • IHImmunohistochemistry
  • IMImmunomicroscopy
  • IOImmunoassay
  • IPImmunoprecipitation
  • ISIntracellular Staining for Flow Cytometry
  • LALuminex Assay
  • LFLateral Flow Immunoassay
  • MMicroarray
  • MCMass Cytometry/CyTOF
  • MDMeDIP
  • MSElectrophoretic Mobility Shift Assay
  • NNeutralization
  • PImmunohistologyp-Paraffin Sections
  • PAPeptide Array
  • PEPeptide ELISA
  • PLProximity Ligation Assay
  • RRadioimmunoassay
  • SStimulation
  • SESandwich ELISA
  • SHIn situ hybridization
  • TCTissue Culture
  • WBWestern Blot
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