RHOT1

RHOT1 (Ras Homolog Family Member T1) is a Protein Coding gene. Among its related pathways are Mitophagy - animal and Metabolism of proteins. Gene Ontology (GO) annotations related to this gene include calcium ion binding and GTPase activity. An important paralog of this gene is RHOT2.

ras homolog gene family, member T1

Mitochondrial GTPase involved in mitochondrial trafficking (PubMed:12482879, PubMed:16630562, PubMed:22396657).
Probably involved in control of anterograde transport of mitochondria and their subcellular distribution (PubMed:12482879, PubMed:16630562, PubMed:22396657).
Promotes mitochondrial fission during high calcium conditions (PubMed:27716788).

Biological Process cellular homeostasisManual Assertion Based On ExperimentIMP:UniProtKB
Biological Process mitochondrial outer membrane permeabilizationManual Assertion Based On ExperimentIMP:UniProtKB
Biological Process mitochondrion organizationManual Assertion Based On ExperimentIBA:GO_Central
Biological Process mitochondrion transport along microtubuleManual Assertion Based On ExperimentIMP:UniProtKB
Biological Process regulation of mitochondrion organizationManual Assertion Based On ExperimentIMP:UniProtKB
Biological Process small GTPase mediated signal transductionIEA:InterPro

Mitochondrion outer membrane
Colocalizes with MGARP and RHOT2 at the mitochondria.

Cytoplasmic: 1-592
Helical: 593-615
Mitochondrial intermembrane: 616-618

Ubiquitinated by PRKN during mitophagy, leading to its degradation and enhancement of mitophagy (PubMed:22396657, PubMed:24896179).
Deubiquitinated by USP30 (PubMed:24896179).