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Mouse Anti-RHOT1 Recombinant Antibody (4H4) (CBMAB-R2606-CN)

This product is a Mouse antibody that recognizes RHOT1. The antibody 4H4 can be used for immunoassay techniques such as: ELISA, WB.
See all RHOT1 antibodies

Summary

Host Animal
Mouse
Specificity
Human
Clone
4H4
Antibody Isotype
IgG1, κ
Application
ELISA, WB

Basic Information

Immunogen
Partial recombinant corresponding to aa. 483-581 from human RHOT1 (NP_060777) with GST tag
Specificity
Human
Antibody Isotype
IgG1, κ
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Buffer
PBS, pH 7.2

Target

Full Name
ras homolog gene family, member T1
Introduction
RHOT1 (Ras Homolog Family Member T1) is a Protein Coding gene. Among its related pathways are Mitophagy - animal and Metabolism of proteins. Gene Ontology (GO) annotations related to this gene include calcium ion binding and GTPase activity. An important paralog of this gene is RHOT2.
Entrez Gene ID
55288
UniProt ID
Q8IXI2
Alternative Names
Ras Homolog Family Member T1; Ras Homolog Gene Family, Member T1; Mitochondrial Rho (MIRO) GTPase 1; MIRO-1; ARHT1; Rac-GTP Binding Protein-Like Protein; Rac-GTP-Binding Protein-Like Protein;
Function
Mitochondrial GTPase involved in mitochondrial trafficking (PubMed:12482879, PubMed:16630562, PubMed:22396657).
Probably involved in control of anterograde transport of mitochondria and their subcellular distribution (PubMed:12482879, PubMed:16630562, PubMed:22396657).
Promotes mitochondrial fission during high calcium conditions (PubMed:27716788).
Biological Process
Biological Process cellular homeostasisManual Assertion Based On ExperimentIMP:UniProtKB
Biological Process mitochondrial outer membrane permeabilizationManual Assertion Based On ExperimentIMP:UniProtKB
Biological Process mitochondrion organizationManual Assertion Based On ExperimentIBA:GO_Central
Biological Process mitochondrion transport along microtubuleManual Assertion Based On ExperimentIMP:UniProtKB
Biological Process regulation of mitochondrion organizationManual Assertion Based On ExperimentIMP:UniProtKB
Biological Process small GTPase mediated signal transductionIEA:InterPro
Cellular Location
Mitochondrion outer membrane
Colocalizes with MGARP and RHOT2 at the mitochondria.
Topology
Cytoplasmic: 1-592
Helical: 593-615
Mitochondrial intermembrane: 616-618
PTM
Ubiquitinated by PRKN during mitophagy, leading to its degradation and enhancement of mitophagy (PubMed:22396657, PubMed:24896179).
Deubiquitinated by USP30 (PubMed:24896179).
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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