RNASE6

The protein encoded by this gene is a member of the ribonuclease A superfamily and functions in the urinary tract. The protein has broad-spectrum antimicrobial activity against pathogenic bacteria. [provided by RefSeq, Nov 2014]

Full Name

Ribonuclease A Family Member K6

Function

Ribonuclease which shows a preference for the pyrimidines uridine and cytosine (PubMed:8836175, PubMed:27013146).
Has potent antibacterial activity against a range of Gram-positive and Gram-negative bacteria, including P.aeruginosa, A.baumanii, M.luteus, S.aureus, E.faecalis, E.faecium, S.saprophyticus and E.coli (PubMed:25075772, PubMed:27089320).
Causes loss of bacterial membrane integrity, and also promotes agglutination of Gram-negative bacteria (PubMed:27089320).
Probably contributes to urinary tract sterility (PubMed:25075772).
Bactericidal activity is independent of RNase activity (PubMed:27089320).

Biological Process

Biological Process antibacterial humoral responseManual Assertion Based On ExperimentIDA:UniProtKB
Biological Process antimicrobial humoral immune response mediated by antimicrobial peptideManual Assertion Based On ExperimentIDA:UniProtKB
Biological Process defense responseManual Assertion Based On ExperimentTAS:ProtInc
Biological Process defense response to Gram-negative bacteriumManual Assertion Based On ExperimentIDA:UniProtKB
Biological Process defense response to Gram-positive bacteriumManual Assertion Based On ExperimentIDA:UniProtKB
Biological Process defense response to virusManual Assertion Based On ExperimentIDA:UniProtKB
Biological Process innate immune responseManual Assertion Based On ExperimentIDA:UniProtKB
Biological Process RNA catabolic processManual Assertion Based On ExperimentTAS:ProtInc
Biological Process RNA phosphodiester bond hydrolysisManual Assertion Based On ExperimentIDA:UniProtKB

Cellular Location

Secreted
Lysosome
Cytoplasmic granule