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Mouse Anti-RNASE6 Recombinant Antibody (CBCNR-558) (CBMAB-R2854-CN)

This product is a Mouse antibody that recognizes RNASE6. The antibody CBCNR-558 can be used for immunoassay techniques such as: WB, ICC, IHC-P, IHC-Fr, ELISA.
See all RNASE6 antibodies

Summary

Host Animal
Mouse
Specificity
Human
Clone
CBCNR-558
Application
WB, ICC, IHC-P, IHC-Fr, ELISA

Basic Information

Immunogen
Ribonuclease A6
Specificity
Human
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Buffer
PBS, pH 7.4, 50% Glycerol
Preservative
0.02% Sodium azide
Concentration
0.5 mg/mL

Target

Full Name
Ribonuclease A Family Member K6
Introduction
The protein encoded by this gene is a member of the ribonuclease A superfamily and functions in the urinary tract. The protein has broad-spectrum antimicrobial activity against pathogenic bacteria. [provided by RefSeq, Nov 2014]
Entrez Gene ID
6039
UniProt ID
Q93091
Alternative Names
Ribonuclease A Family Member K6; Ribonuclease, RNase A Family, K6; RNase K6; RNS6; Testicular Tissue Protein Li 166; Ribonuclease A D1; Ribonuclease K6;
Function
Ribonuclease which shows a preference for the pyrimidines uridine and cytosine (PubMed:8836175, PubMed:27013146).
Has potent antibacterial activity against a range of Gram-positive and Gram-negative bacteria, including P.aeruginosa, A.baumanii, M.luteus, S.aureus, E.faecalis, E.faecium, S.saprophyticus and E.coli (PubMed:25075772, PubMed:27089320).
Causes loss of bacterial membrane integrity, and also promotes agglutination of Gram-negative bacteria (PubMed:27089320).
Probably contributes to urinary tract sterility (PubMed:25075772).
Bactericidal activity is independent of RNase activity (PubMed:27089320).
Biological Process
Biological Process antibacterial humoral responseManual Assertion Based On ExperimentIDA:UniProtKB
Biological Process antimicrobial humoral immune response mediated by antimicrobial peptideManual Assertion Based On ExperimentIDA:UniProtKB
Biological Process defense responseManual Assertion Based On ExperimentTAS:ProtInc
Biological Process defense response to Gram-negative bacteriumManual Assertion Based On ExperimentIDA:UniProtKB
Biological Process defense response to Gram-positive bacteriumManual Assertion Based On ExperimentIDA:UniProtKB
Biological Process defense response to virusManual Assertion Based On ExperimentIDA:UniProtKB
Biological Process innate immune responseManual Assertion Based On ExperimentIDA:UniProtKB
Biological Process RNA catabolic processManual Assertion Based On ExperimentTAS:ProtInc
Biological Process RNA phosphodiester bond hydrolysisManual Assertion Based On ExperimentIDA:UniProtKB
Cellular Location
Secreted
Lysosome
Cytoplasmic granule
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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