Mouse Anti-RNASE6 Recombinant Antibody (CBCNR-558) (CBMAB-R2854-CN)

Name: Mouse Anti-RNASE6 Recombinant Antibody (CBCNR-558)
SKU: CBMAB-R2854-CN
Rating: 5 (1 reviews)

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Datasheet

SDS

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Basic Information

Host Animal

Mouse

Clone

CBCNR-558

Application

WB, ICC, IHC-P, IHC-Fr, ELISA

Immunogen

Ribonuclease A6

Specificity

Human

Application Notes

The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Buffer

PBS, pH 7.4, 50% Glycerol

Preservative

0.02% Sodium azide

Concentration

0.5 mg/mL

More Infomation

Target

Full Name

Ribonuclease A Family Member K6

Introduction

The protein encoded by this gene is a member of the ribonuclease A superfamily and functions in the urinary tract. The protein has broad-spectrum antimicrobial activity against pathogenic bacteria. [provided by RefSeq, Nov 2014]

Entrez Gene ID

6039

UniProt ID

Q93091

Alternative Names

Ribonuclease A Family Member K6; Ribonuclease, RNase A Family, K6; RNase K6; RNS6; Testicular Tissue Protein Li 166; Ribonuclease A D1; Ribonuclease K6;

Function

Ribonuclease which shows a preference for the pyrimidines uridine and cytosine (PubMed:8836175, PubMed:27013146).
Has potent antibacterial activity against a range of Gram-positive and Gram-negative bacteria, including P.aeruginosa, A.baumanii, M.luteus, S.aureus, E.faecalis, E.faecium, S.saprophyticus and E.coli (PubMed:25075772, PubMed:27089320).
Causes loss of bacterial membrane integrity, and also promotes agglutination of Gram-negative bacteria (PubMed:27089320).
Probably contributes to urinary tract sterility (PubMed:25075772).
Bactericidal activity is independent of RNase activity (PubMed:27089320).

Biological Process

Biological Process antibacterial humoral responseManual Assertion Based On ExperimentIDA:UniProtKB
Biological Process antimicrobial humoral immune response mediated by antimicrobial peptideManual Assertion Based On ExperimentIDA:UniProtKB
Biological Process defense responseManual Assertion Based On ExperimentTAS:ProtInc
Biological Process defense response to Gram-negative bacteriumManual Assertion Based On ExperimentIDA:UniProtKB
Biological Process defense response to Gram-positive bacteriumManual Assertion Based On ExperimentIDA:UniProtKB
Biological Process defense response to virusManual Assertion Based On ExperimentIDA:UniProtKB
Biological Process innate immune responseManual Assertion Based On ExperimentIDA:UniProtKB
Biological Process RNA catabolic processManual Assertion Based On ExperimentTAS:ProtInc
Biological Process RNA phosphodiester bond hydrolysisManual Assertion Based On ExperimentIDA:UniProtKB

Cellular Location

Secreted
Lysosome
Cytoplasmic granule

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Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme-Linked Immunospot (ELISpot)
Proteogenomics
Other Protocols

Isotype control

For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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