RNF111

The protein encoded by this gene contains a RING finger domain, a motif known to be involved in protein-protein and protein-DNA interactions. The mouse counterpart of this gene (Rnf111/arkadia) has been shown to genetically interact with the transforming growth factor (TGF) beta-like factor Nodal, and act as a modulator of the nodal signaling cascade, which is essential for the induction of mesoderm during embryonic development. [provided by RefSeq]

Full Name

ring finger protein 111

Function

E3 ubiquitin-protein ligase (PubMed:26656854).
Required for mesoderm patterning during embryonic development (By similarity).
Acts as an enhancer of the transcriptional responses of the SMAD2/SMAD3 effectors, which are activated downstream of BMP (PubMed:14657019, PubMed:16601693).
Acts by mediating ubiquitination and degradation of SMAD inhibitors such as SMAD7, inducing their proteasomal degradation and thereby enhancing the transcriptional activity of TGF-beta and BMP (PubMed:14657019, PubMed:16601693).
In addition to enhance transcription of SMAD2/SMAD3 effectors, also regulates their turnover by mediating their ubiquitination and subsequent degradation, coupling their activation with degradation, thereby ensuring that only effectors 'in use' are degraded (By similarity).
Activates SMAD3/SMAD4-dependent transcription by triggering signal-induced degradation of SNON isoform of SKIL (PubMed:17591695).
Associates with UBE2D2 as an E2 enzyme (PubMed:22411132).
Specifically binds polysumoylated chains via SUMO interaction motifs (SIMs) and mediates ubiquitination of sumoylated substrates (PubMed:23751493).
Catalyzes 'Lys-63'-linked ubiquitination of sumoylated XPC in response to UV irradiation, promoting nucleotide excision repair (PubMed:23751493).
Mediates ubiquitination and degradation of sumoylated PML (By similarity).
The regulation of the BMP-SMAD signaling is however independent of sumoylation and is not dependent of SUMO interaction motifs (SIMs) (By similarity).

Biological Process

Biological Process global genome nucleotide-excision repairTAS:Reactome
Biological Process pattern specification processIEA:Ensembl
Biological Process positive regulation of protein ubiquitinationIEA:Ensembl
Biological Process positive regulation of transcription, DNA-templatedManual Assertion Based On ExperimentIMP:BHF-UCL
Biological Process positive regulation of transforming growth factor beta receptor signaling pathwayManual Assertion Based On ExperimentIBA:GO_Central
Biological Process protein polyubiquitinationIEA:Ensembl
Biological Process protein ubiquitinationManual Assertion Based On ExperimentIMP:BHF-UCL
Biological Process ubiquitin-dependent protein catabolic processManual Assertion Based On ExperimentIBA:GO_Central
Biological Process ubiquitin-dependent SMAD protein catabolic processManual Assertion Based On ExperimentIBA:GO_Central

Cellular Location

Nucleus
Cytoplasm
Nucleus, PML body
Upon TGF-beta treatment, translocates from nucleus to cytosol.