RNF167

RNF167 is an E3 ubiquitin ligase that interacts with TSSC5 (SLC22A18; MIM 602631) and, together with UBCH6 (UBE2E1; MIM 602916), facilitates TSSC5 polyubiquitylation (Yamada and Gorbsky, 2006 [PubMed 16314844]). [supplied by OMIM, Mar 2008]

Full Name

Ring Finger Protein 167

Function

E3 ubiquitin-protein ligase that acts as a regulator of the TORC1 signaling pathway (PubMed:35114100, PubMed:33594058).
Positively regulates the TORC1 signaling pathway independently of arginine levels: acts by catalyzing 'Lys-29'-polyubiquitination and degradation of CASTOR1, releasing the GATOR2 complex from CASTOR1 (PubMed:33594058).
Also negatively regulates the TORC1 signaling pathway in response to leucine deprivation: acts by mediating 'Lys-63'-linked polyubiquitination of SESN2, promoting SESN2-interaction with the GATOR2 complex (PubMed:35114100).
Also involved in protein trafficking and localization (PubMed:23129617, PubMed:23353890, PubMed:24387786, PubMed:27808481, PubMed:32409562).
Acts as a regulator of synaptic transmission by mediating ubiquitination and degradation of AMPAR receptor GluA2/GRIA2 (PubMed:23129617, PubMed:33650289).
Does not catalyze ubiquitination of GluA1/GRIA1 (PubMed:23129617).
Also acts as a regulator of the recycling endosome pathway by mediating ubiquitination of VAMP3 (PubMed:23353890).
Regulates lysosome positioning by catalyzing ubiquitination and degradation of ARL8B (PubMed:27808481).
Plays a role in growth regulation involved in G1/S transition by mediating, possibly by mediating ubiquitination of SLC22A18 (PubMed:16314844).
Acts with a limited set of E2 enzymes, such as UBE2D1 and UBE2N (PubMed:33650289).

Biological Process

Biological Process cellular response to leucine starvationManual Assertion Based On ExperimentIDA:UniProtKB
Biological Process lysosome localizationManual Assertion Based On ExperimentIDA:UniProtKB
Biological Process negative regulation of cell cycleManual Assertion Based On ExperimentIMP:UniProtKB
Biological Process negative regulation of TORC1 signalingManual Assertion Based On ExperimentIDA:UniProtKB
Biological Process organelle localizationManual Assertion Based On ExperimentIMP:UniProtKB
Biological Process protein polyubiquitinationManual Assertion Based On ExperimentIDA:UniProtKB
Biological Process regulation of synaptic transmission, glutamatergicManual Assertion Based On ExperimentIDA:UniProtKB
Biological Process ubiquitin-dependent protein catabolic processManual Assertion Based On ExperimentIBA:GO_Central

Cellular Location

Lysosome membrane
Endosome membrane
Endomembrane system
Cell membrane
Targeted to cytoplasmic membranes; mainly localizes to lysosomal membrane (PubMed:16314844, PubMed:23129617).
A subpopulation localizes to the cell membrane of neurons (PubMed:23129617).
Isoform 1
Lysosome membrane

Topology

Helical: 174-194

PTM

Autoubiquitinated in vitro in the presence of UBE2D1 and UBE2E1.