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Mouse Anti-RNF167 Recombinant Antibody (E-9) (CBMAB-R2959-CN)

This product is a Mouse antibody that recognizes RNF167. The antibody E-9 can be used for immunoassay techniques such as: WB, IP, IF, ELISA.
See all RNF167 antibodies

Summary

Host Animal
Mouse
Specificity
Mouse, Rat, Human
Clone
E-9
Application
WB, IP, IF, ELISA

Basic Information

Specificity
Mouse, Rat, Human
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Target

Full Name
Ring Finger Protein 167
Introduction
RNF167 is an E3 ubiquitin ligase that interacts with TSSC5 (SLC22A18; MIM 602631) and, together with UBCH6 (UBE2E1; MIM 602916), facilitates TSSC5 polyubiquitylation (Yamada and Gorbsky, 2006 [PubMed 16314844]). [supplied by OMIM, Mar 2008]
Entrez Gene ID
Human26001
Mouse70510
Rat360554
UniProt ID
HumanQ9H6Y7
MouseQ91XF4
RatQ5XIL0
Alternative Names
Ring Finger Protein 167; RING-Type E3 Ubiquitin Transferase RNF167; RING Finger Protein 167; RING105; E3 Ubiquitin-Protein Ligase RNF167; 5730408C10Rik; EC 2.3.2.27; LP2254;
Function
E3 ubiquitin-protein ligase that acts as a regulator of the TORC1 signaling pathway (PubMed:35114100, PubMed:33594058).
Positively regulates the TORC1 signaling pathway independently of arginine levels: acts by catalyzing 'Lys-29'-polyubiquitination and degradation of CASTOR1, releasing the GATOR2 complex from CASTOR1 (PubMed:33594058).
Also negatively regulates the TORC1 signaling pathway in response to leucine deprivation: acts by mediating 'Lys-63'-linked polyubiquitination of SESN2, promoting SESN2-interaction with the GATOR2 complex (PubMed:35114100).
Also involved in protein trafficking and localization (PubMed:23129617, PubMed:23353890, PubMed:24387786, PubMed:27808481, PubMed:32409562).
Acts as a regulator of synaptic transmission by mediating ubiquitination and degradation of AMPAR receptor GluA2/GRIA2 (PubMed:23129617, PubMed:33650289).
Does not catalyze ubiquitination of GluA1/GRIA1 (PubMed:23129617).
Also acts as a regulator of the recycling endosome pathway by mediating ubiquitination of VAMP3 (PubMed:23353890).
Regulates lysosome positioning by catalyzing ubiquitination and degradation of ARL8B (PubMed:27808481).
Plays a role in growth regulation involved in G1/S transition by mediating, possibly by mediating ubiquitination of SLC22A18 (PubMed:16314844).
Acts with a limited set of E2 enzymes, such as UBE2D1 and UBE2N (PubMed:33650289).
Biological Process
Biological Process cellular response to leucine starvationManual Assertion Based On ExperimentIDA:UniProtKB
Biological Process lysosome localizationManual Assertion Based On ExperimentIDA:UniProtKB
Biological Process negative regulation of cell cycleManual Assertion Based On ExperimentIMP:UniProtKB
Biological Process negative regulation of TORC1 signalingManual Assertion Based On ExperimentIDA:UniProtKB
Biological Process organelle localizationManual Assertion Based On ExperimentIMP:UniProtKB
Biological Process protein polyubiquitinationManual Assertion Based On ExperimentIDA:UniProtKB
Biological Process regulation of synaptic transmission, glutamatergicManual Assertion Based On ExperimentIDA:UniProtKB
Biological Process ubiquitin-dependent protein catabolic processManual Assertion Based On ExperimentIBA:GO_Central
Cellular Location
Lysosome membrane
Endosome membrane
Endomembrane system
Cell membrane
Targeted to cytoplasmic membranes; mainly localizes to lysosomal membrane (PubMed:16314844, PubMed:23129617).
A subpopulation localizes to the cell membrane of neurons (PubMed:23129617).
Isoform 1
Lysosome membrane
Topology
Helical: 174-194
PTM
Autoubiquitinated in vitro in the presence of UBE2D1 and UBE2E1.
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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