RSC1A1

The protein encoded by this intronless gene inhibits the expression of the solute carrier family 5 (sodium/glucose cotransporter), member 1 gene (SLC5A1) and downregulates exocytosis of the SLC5A1 protein. The encoded protein is sometimes found coating the trans-Golgi network and other times is localized to the nucleus, depending on the cell cycle stage. This protein also inhibits the expression of solute carrier family 22 (organic cation transporter), member 2 (SLC22A2). [provided by RefSeq, Dec 2015]

Full Name

regulatory solute carrier protein, family 1, member 1

Function

Mediates transcriptional and post-transcriptional regulation of SLC5A1. Inhibits a dynamin and PKC-dependent exocytotic pathway of SLC5A1. Also involved in transcriptional regulation of SLC22A2. Exhibits glucose-dependent, short-term inhibition of SLC5A1 and SLC22A2 by inhibiting the release of vesicles from the trans-Golgi network.

Biological Process

Biological Process negative regulation of exocytosisIEA:InterPro
Biological Process negative regulation of glucose transmembrane transportManual Assertion Based On ExperimentIDA:UniProtKB
Biological Process negative regulation of Golgi to plasma membrane protein transportManual Assertion Based On ExperimentIDA:ARUK-UCL
Biological Process negative regulation of nucleoside transportManual Assertion Based On ExperimentIDA:ARUK-UCL
Biological Process negative regulation of protein localization to plasma membraneBy SimilarityISS:ARUK-UCL
Biological Process negative regulation of transportManual Assertion Based On ExperimentIDA:MGI
Biological Process regulation of DNA-templated transcriptionIEA:InterPro

Cellular Location

Cell membrane
Nucleus
Golgi apparatus, trans-Golgi network
Localizes at the inner side of the plasma membrane.