RSPO1
This gene encodes a secreted activator protein with two cysteine-rich, furin-like domains and one thrombospondin type 1 domain. The encoded protein is a ligand for leucine-rich repeat-containing G-protein coupled receptors (LGR proteins) and positively regulates the Wnt signaling pathway. In mice, the protein induces the rapid onset of crypt cell proliferation and increases intestinal epithelial healing, providing a protective effect against chemotherapy-induced adverse effects. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Apr 2014]
Full Name
R-Spondin 1
Function
Activator of the canonical Wnt signaling pathway by acting as a ligand for LGR4-6 receptors (PubMed:29769720).
Upon binding to LGR4-6 (LGR4, LGR5 or LGR6), LGR4-6 associate with phosphorylated LRP6 and frizzled receptors that are activated by extracellular Wnt receptors, triggering the canonical Wnt signaling pathway to increase expression of target genes. Also regulates the canonical Wnt/beta-catenin-dependent pathway and non-canonical Wnt signaling by acting as an inhibitor of ZNRF3, an important regulator of the Wnt signaling pathway. Acts as a ligand for frizzled FZD8 and LRP6. May negatively regulate the TGF-beta pathway. Has a essential roles in ovary determination. Regulates Wnt signaling by antagonizing DKK1/KREM1-mediated internalization of LRP6 through an interaction with KREM1 (PubMed:17804805).
Upon binding to LGR4-6 (LGR4, LGR5 or LGR6), LGR4-6 associate with phosphorylated LRP6 and frizzled receptors that are activated by extracellular Wnt receptors, triggering the canonical Wnt signaling pathway to increase expression of target genes. Also regulates the canonical Wnt/beta-catenin-dependent pathway and non-canonical Wnt signaling by acting as an inhibitor of ZNRF3, an important regulator of the Wnt signaling pathway. Acts as a ligand for frizzled FZD8 and LRP6. May negatively regulate the TGF-beta pathway. Has a essential roles in ovary determination. Regulates Wnt signaling by antagonizing DKK1/KREM1-mediated internalization of LRP6 through an interaction with KREM1 (PubMed:17804805).
Biological Process
Biological Process positive regulation of canonical Wnt signaling pathwayManual Assertion Based On ExperimentIDA:UniProtKB
Biological Process positive regulation of protein phosphorylationManual Assertion Based On ExperimentIDA:UniProtKB
Biological Process positive regulation of Wnt signaling pathwayManual Assertion Based On ExperimentIDA:UniProtKB
Biological Process regulation of receptor internalizationManual Assertion Based On ExperimentIDA:BHF-UCL
Biological Process Wnt signaling pathwayIEA:UniProtKB-KW
Biological Process positive regulation of protein phosphorylationManual Assertion Based On ExperimentIDA:UniProtKB
Biological Process positive regulation of Wnt signaling pathwayManual Assertion Based On ExperimentIDA:UniProtKB
Biological Process regulation of receptor internalizationManual Assertion Based On ExperimentIDA:BHF-UCL
Biological Process Wnt signaling pathwayIEA:UniProtKB-KW
Cellular Location
Secreted
Nucleus
Seems to mainly localize to nucleoli.
Nucleus
Seems to mainly localize to nucleoli.
Involvement in disease
Keratoderma, palmoplantar, with squamous cell carcinoma of skin and sex reversal (PKKSCC):
A recessive syndrome characterized by XX (female to male) SRY-independent sex reversal, palmoplantar hyperkeratosis and predisposition to squamous cell carcinoma of the skin.
A recessive syndrome characterized by XX (female to male) SRY-independent sex reversal, palmoplantar hyperkeratosis and predisposition to squamous cell carcinoma of the skin.
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Anti-RSPO1 antibodies
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CompareTarget: RSPO1
Expressed Host: CHO Stable Cells
Sequence: Amino Acid: 1-265
Tag: His Tag
Target: RSPO1
Expressed Host: CHO Stable Cells
Sequence: Amino Acid: 1-263
Target: RSPO1
Expressed Host: HEK293 Cells
Sequence: Amino Acid: 1-263
Tag: His Tag
Target: RSPO1
Expressed Host: HEK293 Cells
Sequence: Amino Acid: 1-146
Tag: His Tag
Target: RSPO1
Host: Mouse
Antibody Isotype: IgG
Specificity: Human
Clone: CBT1079
Application*: WB, E
Target: RSPO1
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBT4135
Application*: WB
Target: RSPO1
Host: Rat
Antibody Isotype: IgG2b
Specificity: Mouse
Clone: 852010
Application*: N
Target: RSPO1
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: 7A6
Application*: WB, E
Target: RSPO1
Host: Mouse
Antibody Isotype: IgG2b
Specificity: Human, Mouse
Clone: 422407
Application*: WB
Target: RSPO1
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: 2F10
Application*: WB
Target: RSPO1
Host: Mouse
Antibody Isotype: IgG2a
Specificity: Human
Clone: 2B11
Application*: WB
Target: RSPO1
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: 1C3
Application*: WB, IH
Target: RSPO1
Host: Rat
Specificity: Mouse
Clone: 15H132
Application*: N
Target: RSPO1
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: 13B660
Application*: E, WB
Target: RSPO1
Host: Mouse
Antibody Isotype: IgG2b
Specificity: Human
Clone: 11A9
Application*: WB, IH
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For Research Use Only. Not For Clinical Use.
(P): Predicted
* Abbreviations
- AActivation
- AGAgonist
- APApoptosis
- BBlocking
- BABioassay
- BIBioimaging
- CImmunohistochemistry-Frozen Sections
- CIChromatin Immunoprecipitation
- CTCytotoxicity
- CSCostimulation
- DDepletion
- DBDot Blot
- EELISA
- ECELISA(Cap)
- EDELISA(Det)
- ESELISpot
- EMElectron Microscopy
- FFlow Cytometry
- FNFunction Assay
- GSGel Supershift
- IInhibition
- IAEnzyme Immunoassay
- ICImmunocytochemistry
- IDImmunodiffusion
- IEImmunoelectrophoresis
- IFImmunofluorescence
- IGImmunochromatography
- IHImmunohistochemistry
- IMImmunomicroscopy
- IOImmunoassay
- IPImmunoprecipitation
- ISIntracellular Staining for Flow Cytometry
- LALuminex Assay
- LFLateral Flow Immunoassay
- MMicroarray
- MCMass Cytometry/CyTOF
- MDMeDIP
- MSElectrophoretic Mobility Shift Assay
- NNeutralization
- PImmunohistologyp-Paraffin Sections
- PAPeptide Array
- PEPeptide ELISA
- PLProximity Ligation Assay
- RRadioimmunoassay
- SStimulation
- SESandwich ELISA
- SHIn situ hybridization
- TCTissue Culture
- WBWestern Blot
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