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RTN1

This gene belongs to the family of reticulon encoding genes. Reticulons are associated with the endoplasmic reticulum, and are involved in neuroendocrine secretion or in membrane trafficking in neuroendocrine cells. This gene is considered to be a specific marker for neurological diseases and cancer, and is a potential molecular target for therapy. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2011]

Full Name

Reticulon 1

Function

Inhibits amyloid precursor protein processing, probably by blocking BACE1 activity.

Biological Process

Biological Process negative regulation of amyloid-beta formationManual Assertion Based On ExperimentIDA:UniProtKB
Biological Process neuron differentiationIEP:UniProtKB

Cellular Location

Endoplasmic reticulum membrane
Golgi apparatus membrane

PTM

Isoforms RTN1-A and RTN1-B are phosphorylated.

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Anti-RTN1 antibodies

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Mouse Anti-RTN1 Recombinant Antibody (RNL-4) (CBMAB-R3798-CN)

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Target: RTN1

Host: Mouse

Antibody Isotype: IgG1

Specificity: Human, Pig, Rat

Clone: RNL-4

Application*: F, ICC, C, WB

Mouse Anti-RTN1 Recombinant Antibody (RNL-3) (CBMAB-R3797-CN)

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Target: RTN1

Host: Mouse

Antibody Isotype: IgG1

Specificity: Human, Rabbit, Monkey

Clone: RNL-3

Application*: WB, P, C, IF, F

Mouse Anti-RTN1 Recombinant Antibody (RNL-2) (CBMAB-R3796-CN)

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Target: RTN1

Host: Mouse

Antibody Isotype: IgG1

Specificity: Human, Rabbit, Monkey

Clone: RNL-2

Application*: WB, P, C, IF, F

Mouse Anti-RTN1 Recombinant Antibody (559706) (CBMAB-R3793-CN)

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Target: RTN1

Host: Mouse

Antibody Isotype: IgG1

Specificity: Rat

Clone: 559706

Application*: IH

Mouse Anti-RTN1 Recombinant Antibody (1988) (CBMAB-R3792-CN)

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Target: RTN1

Host: Mouse

Antibody Isotype: IgG1

Specificity: Human

Clone: 1988

Application*: WB, F, IH, IF, C, MC

Mouse Anti-RTN1 Recombinant Antibody (MON160) (CBMAB-R0364-CN)

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Target: RTN1

Host: Mouse

Antibody Isotype: IgG1

Specificity: Human, Mouse, Rat, Hamster

Clone: MON160

Application*: WB, F, IH, IF, P, C, MC

Mouse Anti-RTN1 Recombinant Antibody (MON162) (CBMAB-1784-CN)

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Target: RTN1

Host: Mouse

Antibody Isotype: IgG1

Specificity: Human, Mouse, Rat, Hamster, Pig

Clone: MON162

Application*: F, IC, C, P, WB

Mouse Anti-RTN1 Recombinant Antibody (RNL3) (CBMAB-1783-CN)

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Target: RTN1

Host: Mouse

Antibody Isotype: IgG1

Specificity: Human

Clone: RNL3

Application*: P

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(P): Predicted

* Abbreviations

AActivation
AGAgonist
APApoptosis
BBlocking
BABioassay
BIBioimaging
CImmunohistochemistry-Frozen Sections
CIChromatin Immunoprecipitation
CTCytotoxicity
CSCostimulation
DDepletion
DBDot Blot

EELISA
ECELISA(Cap)
EDELISA(Det)
ESELISpot
EMElectron Microscopy
FFlow Cytometry
FNFunction Assay
GSGel Supershift
IInhibition
IAEnzyme Immunoassay
ICImmunocytochemistry
IDImmunodiffusion
IEImmunoelectrophoresis

IFImmunofluorescence
IGImmunochromatography
IHImmunohistochemistry
IMImmunomicroscopy
IOImmunoassay
IPImmunoprecipitation
ISIntracellular Staining for Flow Cytometry
LALuminex Assay
LFLateral Flow Immunoassay
MMicroarray
MCMass Cytometry/CyTOF
MDMeDIP

MSElectrophoretic Mobility Shift Assay
NNeutralization
PImmunohistologyp-Paraffin Sections
PAPeptide Array
PEPeptide ELISA
PLProximity Ligation Assay
RRadioimmunoassay
SStimulation
SESandwich ELISA
SHIn situ hybridization
TCTissue Culture
WBWestern Blot

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