RTN1

This gene belongs to the family of reticulon encoding genes. Reticulons are associated with the endoplasmic reticulum, and are involved in neuroendocrine secretion or in membrane trafficking in neuroendocrine cells. This gene is considered to be a specific marker for neurological diseases and cancer, and is a potential molecular target for therapy. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2011]

Reticulon 1

Inhibits amyloid precursor protein processing, probably by blocking BACE1 activity.

Biological Process negative regulation of amyloid-beta formationManual Assertion Based On ExperimentIDA:UniProtKB
Biological Process neuron differentiationIEP:UniProtKB

Endoplasmic reticulum membrane
Golgi apparatus membrane

Isoforms RTN1-A and RTN1-B are phosphorylated.