Mouse Anti-RTN1 Recombinant Antibody (MON160) (CBMAB-R0364-CN)

Name: Mouse Anti-RTN1 Recombinant Antibody (MON160)
SKU: CBMAB-R0364-CN
Rating: 5 (1 reviews)

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Datasheet

SDS

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Basic Information

Host Animal

Mouse

Clone

MON160

Application

WB, FC, IHC, IF, IHC-P, IHC-Fr, CyTOF

Immunogen

A partially purified bacterially expressed Reticulon 1A (NSP-A) hybrid protein (beta -GAL-NSP-A 6-776), aa. 174-337

Specificity

Human, Mouse, Rat, Hamster

Antibody Isotype

IgG1

Clonality

Monoclonal

Application Notes

The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Concentration

1 mg/mL

More Infomation

Target

Full Name

Reticulon 1

Introduction

This gene belongs to the family of reticulon encoding genes. Reticulons are associated with the endoplasmic reticulum, and are involved in neuroendocrine secretion or in membrane trafficking in neuroendocrine cells. This gene is considered to be a specific marker for neurological diseases and cancer, and is a potential molecular target for therapy. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2011]

Entrez Gene ID

Human	6252
Mouse	104001
Rat	116644
Hamster	101835589

UniProt ID

Human	Q16799
Mouse	Q8K0T0
Rat	Q64548
Hamster	A0A1U7Q8H4

Alternative Names

Reticulon 1; Neuroendocrine-Specific Protein; NSP; Reticulon-1;

Function

Inhibits amyloid precursor protein processing, probably by blocking BACE1 activity.

Biological Process

Biological Process negative regulation of amyloid-beta formationManual Assertion Based On ExperimentIDA:UniProtKB
Biological Process neuron differentiationIEP:UniProtKB

Cellular Location

Endoplasmic reticulum membrane
Golgi apparatus membrane

PTM

Isoforms RTN1-A and RTN1-B are phosphorylated.

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Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme Linked Immunospot (ELISpot)
Proteogenomic
Other Protocols

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Isotype control

For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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