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Mouse Anti-RTN1 Recombinant Antibody (MON160) (CBMAB-R0364-CN)

This product is a Mouse antibody that recognizes RTN1. The antibody MON160 can be used for immunoassay techniques such as: WB, FC, IHC, IF, IHC-P, IHC-Fr, CyTOF.
See all RTN1 antibodies
Published Data
Fig.1 Representative immunostaining of RTN1A in kidney sections of patients with minimal change disease HIVAN (n=5). Immunostaining was performed in duplicates.
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Fig.2 Western blots of total protein lysates from Glom and Cortex.
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Fig.3 Flow cytometric analysis of HK2 cells for apoptosis after double labelling with Annexin V and propidium iodide.
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Fig.4 Rtn1asiRNA (shRNA) was fed with DOX for 3 weeks before the surgery.
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Summary

Host Animal
Mouse
Specificity
Human, Mouse, Rat, Hamster
Clone
MON160
Antibody Isotype
IgG1
Application
WB, FC, IHC, IF, IHC-P, IHC-Fr, CyTOF

Basic Information

Immunogen
A partially purified bacterially expressed Reticulon 1A (NSP-A) hybrid protein (beta -GAL-NSP-A 6-776), aa. 174-337
Specificity
Human, Mouse, Rat, Hamster
Antibody Isotype
IgG1
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Concentration
1 mg/mL

Target

Full Name
Reticulon 1
Introduction
This gene belongs to the family of reticulon encoding genes. Reticulons are associated with the endoplasmic reticulum, and are involved in neuroendocrine secretion or in membrane trafficking in neuroendocrine cells. This gene is considered to be a specific marker for neurological diseases and cancer, and is a potential molecular target for therapy. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2011]
Entrez Gene ID
Human6252
Mouse104001
Rat116644
Hamster101835589
UniProt ID
HumanQ16799
MouseQ8K0T0
RatQ64548
HamsterA0A1U7Q8H4
Alternative Names
Reticulon 1; Neuroendocrine-Specific Protein; NSP; Reticulon-1;
Function
Inhibits amyloid precursor protein processing, probably by blocking BACE1 activity.
Biological Process
Biological Process negative regulation of amyloid-beta formationManual Assertion Based On ExperimentIDA:UniProtKB
Biological Process neuron differentiationIEP:UniProtKB
Cellular Location
Endoplasmic reticulum membrane
Golgi apparatus membrane
PTM
Isoforms RTN1-A and RTN1-B are phosphorylated.
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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