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Mouse Anti-RTN1 Recombinant Antibody (RNL3) (CBMAB-1783-CN)

This product is a mouse antibody that recognizes RTN1 of human. The antibody RNL3 can be used for immunoassay techniques such as: IHC-P.
See all RTN1 antibodies

Summary

Host Animal
Mouse
Specificity
Human
Clone
RNL3
Antibody Isotype
IgG1
Application
IHC-P

Basic Information

Immunogen
Tissue, cells or virus corresponding to Human Reticulon 1. This antibody was raised against small cell lung cancer cell line NCI-H82.
Specificity
Human
Antibody Isotype
IgG1
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Buffer
99% PBS
Preservative
0.09% Sodium azide
Concentration
1 mg/mL
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.
Epitope
Localized in aa. 421-589

Target

Full Name
Reticulon 1
Introduction
This gene belongs to the family of reticulon encoding genes. Reticulons are associated with the endoplasmic reticulum, and are involved in neuroendocrine secretion or in membrane trafficking in neuroendocrine cells. This gene is considered to be a specific marker for neurological diseases and cancer, and is a potential molecular target for therapy. The protein may be involved in neuroendocrine secretion or in membrane trafficking in neuroendocrine cells.
Entrez Gene ID
6252
UniProt ID
Q16799
Alternative Names
NSP
Function
Inhibits amyloid precursor protein processing, probably by blocking BACE1 activity.
Biological Process
Biological Process negative regulation of amyloid-beta formationManual Assertion Based On ExperimentIDA:UniProtKB
Biological Process neuron differentiationIEP:UniProtKB
Cellular Location
Endoplasmic reticulum membrane
Golgi apparatus membrane
PTM
Isoforms RTN1-A and RTN1-B are phosphorylated.
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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