RTN4R

This gene encodes the receptor for reticulon 4, oligodendrocyte myelin glycoprotein and myelin-associated glycoprotein. This receptor mediates axonal growth inhibition and may play a role in regulating axonal regeneration and plasticity in the adult central nervous system. [provided by RefSeq, Jul 2008]

Full Name

Reticulon 4 Receptor

Function

Receptor for RTN4, OMG and MAG (PubMed:12037567, PubMed:12068310, PubMed:12426574, PubMed:12089450, PubMed:16712417, PubMed:18411262, PubMed:12839991, PubMed:19052207).
Functions as receptor for the sialylated gangliosides GT1b and GM1 (PubMed:18411262).
Besides, functions as receptor for chondroitin sulfate proteoglycans (By similarity).
Can also bind heparin (By similarity).
Intracellular signaling cascades are triggered via the coreceptor NGFR (PubMed:12426574).
Signaling mediates activation of Rho and downstream reorganization of the actin cytoskeleton (PubMed:16712417, PubMed:22325200).
Mediates axonal growth inhibition (PubMed:12839991, PubMed:19052207, PubMed:28892071).
Plays a role in regulating axon regeneration and neuronal plasticity in the adult central nervous system. Plays a role in postnatal brain development. Required for normal axon migration across the brain midline and normal formation of the corpus callosum. Protects motoneurons against apoptosis; protection against apoptosis is probably mediated via interaction with MAG. Acts in conjunction with RTN4 and LINGO1 in regulating neuronal precursor cell motility during cortical development. Like other family members, plays a role in restricting the number dendritic spines and the number of synapses that are formed during brain development (PubMed:22325200).

Biological Process

Biological Process axonogenesisIEA:Ensembl
Biological Process cell surface receptor signaling pathwayISS:UniProtKB
Biological Process corpus callosum developmentISS:UniProtKB
Biological Process negative regulation of axon extensionISS:UniProtKB
Biological Process negative regulation of axon regenerationISS:UniProtKB
Biological Process negative regulation of neuron projection developmentISS:UniProtKB
Biological Process neuronal signal transductionISS:UniProtKB
Biological Process positive regulation of GTPase activityISS:UniProtKB
Biological Process positive regulation of Rho protein signal transductionManual Assertion Based On ExperimentIMP:UniProtKB

Cellular Location

Cell membrane
Membrane raft
Cell projection, dendrite
Cell projection, axon
Perikaryon
Detected along dendrites and axons, close to synapses, but clearly excluded from synapses.

Involvement in disease

Schizophrenia (SCZD):
A complex, multifactorial psychotic disorder or group of disorders characterized by disturbances in the form and content of thought (e.g. delusions, hallucinations), in mood (e.g. inappropriate affect), in sense of self and relationship to the external world (e.g. loss of ego boundaries, withdrawal), and in behavior (e.g bizarre or apparently purposeless behavior). Although it affects emotions, it is distinguished from mood disorders in which such disturbances are primary. Similarly, there may be mild impairment of cognitive function, and it is distinguished from the dementias in which disturbed cognitive function is considered primary. Some patients manifest schizophrenic as well as bipolar disorder symptoms and are often given the diagnosis of schizoaffective disorder.

PTM

N-glycosylated. O-glycosylated. Contains terminal sialic acid groups on its glycan chains.