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Rat Anti-RTN4R Recombinant Antibody (3D66) (CBMAB-R3816-CN)

This product is a Rat antibody that recognizes RTN4R. The antibody 3D66 can be used for immunoassay techniques such as: WB.
See all RTN4R antibodies

Summary

Host Animal
Rat
Specificity
Mouse
Clone
3D66
Antibody Isotype
IgG2
Application
WB

Basic Information

Immunogen
Purified Mouse Recombinant Nogo receptor extracellular domain
Specificity
Mouse
Antibody Isotype
IgG2
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Target

Full Name
Reticulon 4 Receptor
Introduction
This gene encodes the receptor for reticulon 4, oligodendrocyte myelin glycoprotein and myelin-associated glycoprotein. This receptor mediates axonal growth inhibition and may play a role in regulating axonal regeneration and plasticity in the adult central nervous system. [provided by RefSeq, Jul 2008]
Entrez Gene ID
UniProt ID
Alternative Names
Reticulon 4 Receptor; Nogo-66 Receptor; Nogo Receptor; NOGOR; NGR; Reticulon-4 Receptor; UNQ330/PRO526;
Function
Receptor for RTN4, OMG and MAG (PubMed:12037567, PubMed:12068310, PubMed:12426574, PubMed:12089450, PubMed:16712417, PubMed:18411262, PubMed:12839991, PubMed:19052207).
Functions as receptor for the sialylated gangliosides GT1b and GM1 (PubMed:18411262).
Besides, functions as receptor for chondroitin sulfate proteoglycans (By similarity).
Can also bind heparin (By similarity).
Intracellular signaling cascades are triggered via the coreceptor NGFR (PubMed:12426574).
Signaling mediates activation of Rho and downstream reorganization of the actin cytoskeleton (PubMed:16712417, PubMed:22325200).
Mediates axonal growth inhibition (PubMed:12839991, PubMed:19052207, PubMed:28892071).
Plays a role in regulating axon regeneration and neuronal plasticity in the adult central nervous system. Plays a role in postnatal brain development. Required for normal axon migration across the brain midline and normal formation of the corpus callosum. Protects motoneurons against apoptosis; protection against apoptosis is probably mediated via interaction with MAG. Acts in conjunction with RTN4 and LINGO1 in regulating neuronal precursor cell motility during cortical development. Like other family members, plays a role in restricting the number dendritic spines and the number of synapses that are formed during brain development (PubMed:22325200).
Biological Process
Biological Process axonogenesisIEA:Ensembl
Biological Process cell surface receptor signaling pathwayISS:UniProtKB
Biological Process corpus callosum developmentISS:UniProtKB
Biological Process negative regulation of axon extensionISS:UniProtKB
Biological Process negative regulation of axon regenerationISS:UniProtKB
Biological Process negative regulation of neuron projection developmentISS:UniProtKB
Biological Process neuronal signal transductionISS:UniProtKB
Biological Process positive regulation of GTPase activityISS:UniProtKB
Biological Process positive regulation of Rho protein signal transductionManual Assertion Based On ExperimentIMP:UniProtKB
Cellular Location
Cell membrane
Membrane raft
Cell projection, dendrite
Cell projection, axon
Perikaryon
Detected along dendrites and axons, close to synapses, but clearly excluded from synapses.
Involvement in disease
Schizophrenia (SCZD):
A complex, multifactorial psychotic disorder or group of disorders characterized by disturbances in the form and content of thought (e.g. delusions, hallucinations), in mood (e.g. inappropriate affect), in sense of self and relationship to the external world (e.g. loss of ego boundaries, withdrawal), and in behavior (e.g bizarre or apparently purposeless behavior). Although it affects emotions, it is distinguished from mood disorders in which such disturbances are primary. Similarly, there may be mild impairment of cognitive function, and it is distinguished from the dementias in which disturbed cognitive function is considered primary. Some patients manifest schizophrenic as well as bipolar disorder symptoms and are often given the diagnosis of schizoaffective disorder.
PTM
N-glycosylated. O-glycosylated. Contains terminal sialic acid groups on its glycan chains.
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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