SARS-CoV-2 NP

The newly identified 2019 novel coronavirus (SARS-CoV-2) has caused more than 11,900 laboratory-confirmed human infections, including 259 deaths, posing a serious threat to human health.

Full Name

2019 Novel Coronavirus Nucleocapsid Protein

Function

Packages the positive strand viral genome RNA into a helical ribonucleocapsid (RNP) and plays a fundamental role during virion assembly through its interactions with the viral genome and membrane protein M. Plays an important role in enhancing the efficiency of subgenomic viral RNA transcription as well as viral replication (By similarity).
May induce inflammasome responses in cultured cells and mice. Acts by interacting with host NLRP3 to facilitate inflammasome assembly, which induces cytokine release that may play a role in COVID lung injury.

Biological Process

Biological Process negative regulation of interferon-beta productionManual Assertion Based On ExperimentIDA:ComplexPortal
Biological Process positive regulation of NLRP3 inflammasome complex assemblyManual Assertion Based On ExperimentIDA:UniProtKB
Biological Process response to host immune responseManual Assertion Based On ExperimentIDA:DisProt
Biological Process viral RNA genome packaging1 PublicationIC:ComplexPortal

Cellular Location

Virion
Host cytoplasm
Located inside the virion, complexed with the viral RNA. Probably associates with ER-derived membranes where it participates in viral RNA synthesis and virus budding.

PTM

ADP-ribosylated. The ADP-ribosylation is retained in the virion during infection.
Phosphorylated on serine residues by host GSK3A and GSK3B.