SARS-CoV-2 ORF7a

Full Name

SARS-CoV-2 ORF7a

Function

Plays a pivotal role in viral transcription by stimulating both nsp14 3'-5' exoribonuclease and nsp16 2'-O-methyltransferase activities. Therefore plays an essential role in viral mRNAs cap methylation.
Responsible for replication and transcription of the viral RNA genome.

Biological Process

Biological Process DNA-templated transcriptionIEA:InterPro
Biological Process induction by virus of catabolism of host mRNAIEA:UniProtKB-KW
Biological Process induction by virus of host autophagyIEA:UniProtKB-KW
Biological Process modulation by virus of host protein ubiquitinationIEA:UniProtKB-KW
Biological Process proteolysisIEA:UniProtKB-KW
Biological Process suppression by virus of host gene expressionIEA:UniProtKB-KW
Biological Process suppression by virus of host ISG15-protein conjugationIEA:UniProtKB-KW
Biological Process suppression by virus of host NF-kappaB cascadeIEA:UniProtKB-KW
Biological Process suppression by virus of host type I interferon-mediated signaling pathwayIEA:UniProtKB-KW
Biological Process viral protein processingIEA:InterPro
Biological Process viral RNA genome replicationIEA:InterPro

Cellular Location

Cytoplasm
Endoplasmic reticulum-Golgi intermediate compartment
Host cytoplasm, host perinuclear region
Host endoplasmic reticulum-Golgi intermediate compartment
Host membrane
Membrane