SEMA3B

The protein encoded by this gene belongs to the class-3 semaphorin/collapsin family, whose members function in growth cone guidance during neuronal development. This family member inhibits axonal extension and has been shown to act as a tumor suppressor by inducing apoptosis. Alternative splicing of this gene results in multiple transcript variants. [provided by RefSeq, Feb 2014]

Full Name

Semaphorin 3B

Function

Inhibits axonal extension by providing local signals to specify territories inaccessible for growing axons.

Biological Process

Biological Process axon guidanceManual Assertion Based On ExperimentIBA:GO_Central
Biological Process cell-cell signalingManual Assertion Based On ExperimentTAS:ProtInc
Biological Process chemorepulsion of axonManual Assertion Based On ExperimentTAS:ARUK-UCL
Biological Process negative chemotaxisManual Assertion Based On ExperimentIBA:GO_Central
Biological Process negative regulation of axon extension involved in axon guidanceManual Assertion Based On ExperimentIBA:GO_Central
Biological Process neural crest cell migrationManual Assertion Based On ExperimentIBA:GO_Central
Biological Process positive regulation of cell migrationManual Assertion Based On ExperimentIBA:GO_Central
Biological Process semaphorin-plexin signaling pathwayManual Assertion Based On ExperimentIBA:GO_Central

Cellular Location

Secreted
Endoplasmic reticulum
Accumulates in the endoplasmic reticulum.