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Rat Anti-SEMA3B Recombinant Antibody (CBXS-1973) (CBMAB-S4745-CQ)


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Summary

Host Animal
Rat
Specificity
Mouse
Clone
CBXS-1973
Antibody Isotype
IgG2a
Application
WB, ICC

Basic Information

Immunogen
NS0-derived recombinant mouse Semaphorin 3B, Pro26-Pro722, Accession # Q62177
Specificity
Mouse
Antibody Isotype
IgG2a
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Lyophilized
Concentration
LYOPH
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
Semaphorin 3B
Introduction
The protein encoded by this gene belongs to the class-3 semaphorin/collapsin family, whose members function in growth cone guidance during neuronal development. This family member inhibits axonal extension and has been shown to act as a tumor suppressor by inducing apoptosis. Alternative splicing of this gene results in multiple transcript variants.
Entrez Gene ID
20347
UniProt ID
M9MMK0
Alternative Names
SemA; Semaa; sema5; semaV
Function
Inhibits axonal extension by providing local signals to specify territories inaccessible for growing axons.
Biological Process
Biological Process axon guidanceManual Assertion Based On ExperimentIBA:GO_Central
Biological Process cell-cell signalingManual Assertion Based On ExperimentTAS:ProtInc
Biological Process chemorepulsion of axonManual Assertion Based On ExperimentTAS:ARUK-UCL
Biological Process negative chemotaxisManual Assertion Based On ExperimentIBA:GO_Central
Biological Process negative regulation of axon extension involved in axon guidanceManual Assertion Based On ExperimentIBA:GO_Central
Biological Process neural crest cell migrationManual Assertion Based On ExperimentIBA:GO_Central
Biological Process positive regulation of cell migrationManual Assertion Based On ExperimentIBA:GO_Central
Biological Process semaphorin-plexin signaling pathwayManual Assertion Based On ExperimentIBA:GO_Central
Cellular Location
Secreted
Endoplasmic reticulum
Accumulates in the endoplasmic reticulum.
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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