SENP8

NEDD8 (MIM 603171) is a ubiquitin-like protein that becomes conjugated to the cullin (see CUL1; MIM 603134) subunit of several ubiquitin ligases. This conjugation, called neddylation, is required for optimal ubiquitin ligase activity. NEDD8-specific deneddylases, such as NEDP1, or DEN1, are required to process the NEDD8 propeptide at a C-terminal diglycine motif and to remove NEDD8 from cullins (Gan-Erdene et al., 2003 [PubMed 12759363]).[supplied by OMIM
Full Name
SUMO/sentrin specific peptidase family member 8
Function
Protease that catalyzes two essential functions in the NEDD8 pathway: processing of full-length NEDD8 to its mature form and deconjugation of NEDD8 from targeted proteins such as cullins or p53.
Biological Process
Biological Process post-translational protein modificationTAS:Reactome
Biological Process protein deneddylationManual Assertion Based On ExperimentIBA:GO_Central
Biological Process protein deubiquitinationTAS:Reactome
Cellular Location
Cytosol
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Anti-SENP8 antibodies

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Mouse Anti-SENP8 Recombinant Antibody (2E1) (CBMAB-A7972-LY)

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Target: SENP8
Host: Mouse
Antibody Isotype: IgG2a, κ
Specificity: Human
Clone: 2E1
Application*: WB, E
Datasheet SDS

Mouse Anti-SENP8 Recombinant Antibody (CBXS-2885) (CBMAB-S5634-CQ)

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Target: SENP8
Host: Mouse
Antibody Isotype: IgG2a, κ
Specificity: Human
Clone: CBXS-2885
Application*: E, WB
Datasheet SDS

Mouse Anti-SENP8 Recombinant Antibody (CBXS-4866) (CBMAB-S2089-CQ)

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Target: SENP8
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBXS-4866
Application*: P, WB
Datasheet SDS

Mouse Anti-SENP8 Recombinant Antibody (3E4) (CBMAB-N4252-WJ)

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Target: SENP8
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: 3E4
Application*: WB, IH
Datasheet SDS

Human Recombinant SENP8, Active protein, His Tag (V2LY-0526-LY6712)

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Target: SENP8
Expressed Host: E. coli
Sequence: Amino Acid: Full Length
Tag: His Tag
Datasheet SDS
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(P): Predicted
* Abbreviations
  • AActivation
  • AGAgonist
  • APApoptosis
  • BBlocking
  • BABioassay
  • BIBioimaging
  • CImmunohistochemistry-Frozen Sections
  • CIChromatin Immunoprecipitation
  • CTCytotoxicity
  • CSCostimulation
  • DDepletion
  • DBDot Blot
  • EELISA
  • ECELISA(Cap)
  • EDELISA(Det)
  • ESELISpot
  • EMElectron Microscopy
  • FFlow Cytometry
  • FNFunction Assay
  • GSGel Supershift
  • IInhibition
  • IAEnzyme Immunoassay
  • ICImmunocytochemistry
  • IDImmunodiffusion
  • IEImmunoelectrophoresis
  • IFImmunofluorescence
  • IGImmunochromatography
  • IHImmunohistochemistry
  • IMImmunomicroscopy
  • IOImmunoassay
  • IPImmunoprecipitation
  • ISIntracellular Staining for Flow Cytometry
  • LALuminex Assay
  • LFLateral Flow Immunoassay
  • MMicroarray
  • MCMass Cytometry/CyTOF
  • MDMeDIP
  • MSElectrophoretic Mobility Shift Assay
  • NNeutralization
  • PImmunohistologyp-Paraffin Sections
  • PAPeptide Array
  • PEPeptide ELISA
  • PLProximity Ligation Assay
  • RRadioimmunoassay
  • SStimulation
  • SESandwich ELISA
  • SHIn situ hybridization
  • TCTissue Culture
  • WBWestern Blot
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