SERPINA10
The protein encoded by this gene belongs to the serpin family. It is predominantly expressed in the liver and secreted in plasma. It inhibits the activity of coagulation factors Xa and XIa in the presence of protein Z, calcium and phospholipid. Mutations in this gene are associated with venous thrombosis. Alternatively spliced transcript variants have been found for this gene.[provided by RefSeq, May 2010]
Full Name
Serpin Family A Member 10
Function
Inhibits activity of the coagulation protease factor Xa in the presence of PROZ, calcium and phospholipids. Also inhibits factor XIa in the absence of cofactors.
Biological Process
Biological Process blood coagulationIEA:UniProtKB-KW
Biological Process liver regenerationIEA:Ensembl
Biological Process negative regulation of endopeptidase activityManual Assertion Based On ExperimentIBA:GO_Central
Biological Process liver regenerationIEA:Ensembl
Biological Process negative regulation of endopeptidase activityManual Assertion Based On ExperimentIBA:GO_Central
Cellular Location
Secreted
PTM
Phosphorylated by FAM20C in the extracellular medium.
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Anti-SERPINA10 antibodies
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Target: SERPINA10
Specificity: Human
Target: SERPINA10
Host: Mouse
Antibody Isotype: IgG2a, κ
Specificity: Human
Clone: CBXS-2754
Application*: E, IP, WB
Target: SERPINA10
Host: Mouse
Antibody Isotype: IgG
Specificity: Human
Clone: CBYC-P829
Application*: WB, IC, P, C, E
Target: SERPINA10
Host: Mouse
Antibody Isotype: IgG2a, κ
Specificity: Human
Clone: 1E11
Application*: WB, E
Target: SERPINA10
Host: Mouse
Antibody Isotype: IgG2b
Specificity: Human
Clone: CBXS-1968
Application*: WB
Target: SERPINA10
Host: Rabbit
Antibody Isotype: IgG
Specificity: Human
Clone: CBXS-1303
Application*: WB, IP
Target: SERPINA10
Host: Mouse
Antibody Isotype: IgG2a
Specificity: Human, Pig, Rat
Clone: CBXS-5731
Application*: E, IF, IH, WB
Target: SERPINA10
Sensitivity: 0.057 μg/mL
Detection Range: 0.1-40 μg/mL
Sample Type: Serum, Plasma, cell culture supernates
Specificity: Human
Assay Type: Sandwich
Reactivity: Human
Target: Serpina10
Sensitivity: 0.1 ng/mL
Detection Range: 0.02-4.5 ng/mL
Sample Type: Serum, Plasma, cell culture supernates
Specificity: Mouse
Assay Type: Sandwich
Reactivity: Mouse
Target: SERPINA10
Expressed Host: HEK293 Cells
Sequence: Amino Acid: 1-448
Tag: His Tag
Target: SERPINA10
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CF390
Application*: ELISA, WB, IHC, IF
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For Research Use Only. Not For Clinical Use.
(P): Predicted
* Abbreviations
- AActivation
- AGAgonist
- APApoptosis
- BBlocking
- BABioassay
- BIBioimaging
- CImmunohistochemistry-Frozen Sections
- CIChromatin Immunoprecipitation
- CTCytotoxicity
- CSCostimulation
- DDepletion
- DBDot Blot
- EELISA
- ECELISA(Cap)
- EDELISA(Det)
- ESELISpot
- EMElectron Microscopy
- FFlow Cytometry
- FNFunction Assay
- GSGel Supershift
- IInhibition
- IAEnzyme Immunoassay
- ICImmunocytochemistry
- IDImmunodiffusion
- IEImmunoelectrophoresis
- IFImmunofluorescence
- IGImmunochromatography
- IHImmunohistochemistry
- IMImmunomicroscopy
- IOImmunoassay
- IPImmunoprecipitation
- ISIntracellular Staining for Flow Cytometry
- LALuminex Assay
- LFLateral Flow Immunoassay
- MMicroarray
- MCMass Cytometry/CyTOF
- MDMeDIP
- MSElectrophoretic Mobility Shift Assay
- NNeutralization
- PImmunohistologyp-Paraffin Sections
- PAPeptide Array
- PEPeptide ELISA
- PLProximity Ligation Assay
- RRadioimmunoassay
- SStimulation
- SESandwich ELISA
- SHIn situ hybridization
- TCTissue Culture
- WBWestern Blot
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