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SFXN3

SFXN3 (Sideroflexin 3) is a Protein Coding gene. Among its related pathways are Validated targets of C-MYC transcriptional repression. Gene Ontology (GO) annotations related to this gene include cation transmembrane transporter activity and ion transmembrane transporter activity. An important paralog of this gene is SFXN1.

Full Name

sideroflexin 3

Function

Mitochondrial serine transporter that mediates transport of serine into mitochondria, an important step of the one-carbon metabolism pathway (PubMed:30442778).
Mitochondrial serine is converted to glycine and formate, which then exits to the cytosol where it is used to generate the charged folates that serve as one-carbon donors (PubMed:30442778).

Biological Process

Biological Process mitochondrial transmembrane transportManual Assertion Based On ExperimentIDA:UniProtKB
Biological Process one-carbon metabolic processManual Assertion Based On ExperimentIDA:UniProtKB
Biological Process serine import into mitochondrionManual Assertion Based On ExperimentIDA:UniProtKB

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Anti-SFXN3 antibodies

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Mouse Anti-SFXN3 Recombinant Antibody (CBXS-3155) (CBMAB-S5897-CQ)

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Target: SFXN3

Host: Mouse

Antibody Isotype: IgG2b, κ

Specificity: Human

Clone: CBXS-3155

Application*: E, WB

Rabbit Anti-SFXN3 Recombinant Antibody (CBXS-1370) (CBMAB-S4228-CQ)

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Target: SFXN3

Host: Rabbit

Antibody Isotype: IgG

Specificity: Mouse, Rat, Human

Clone: CBXS-1370

Application*: WB, P

Mouse Anti-SFXN3 Recombinant Antibody (CBXS-0330) (CBMAB-S3301-CQ)

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Target: SFXN3

Host: Mouse

Antibody Isotype: IgG2b, κ

Specificity: Human

Clone: CBXS-0330

Application*: SE, WB, E

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Fig.3 Signaling pathways in cancers. (Creative Biolabs Authorized)

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(P): Predicted

* Abbreviations

AActivation
AGAgonist
APApoptosis
BBlocking
BABioassay
BIBioimaging
CImmunohistochemistry-Frozen Sections
CIChromatin Immunoprecipitation
CTCytotoxicity
CSCostimulation
DDepletion
DBDot Blot

EELISA
ECELISA(Cap)
EDELISA(Det)
ESELISpot
EMElectron Microscopy
FFlow Cytometry
FNFunction Assay
GSGel Supershift
IInhibition
IAEnzyme Immunoassay
ICImmunocytochemistry
IDImmunodiffusion
IEImmunoelectrophoresis

IFImmunofluorescence
IGImmunochromatography
IHImmunohistochemistry
IMImmunomicroscopy
IOImmunoassay
IPImmunoprecipitation
ISIntracellular Staining for Flow Cytometry
LALuminex Assay
LFLateral Flow Immunoassay
MMicroarray
MCMass Cytometry/CyTOF
MDMeDIP

MSElectrophoretic Mobility Shift Assay
NNeutralization
PImmunohistologyp-Paraffin Sections
PAPeptide Array
PEPeptide ELISA
PLProximity Ligation Assay
RRadioimmunoassay
SStimulation
SESandwich ELISA
SHIn situ hybridization
TCTissue Culture
WBWestern Blot

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