SFXN3

SFXN3 (Sideroflexin 3) is a Protein Coding gene. Among its related pathways are Validated targets of C-MYC transcriptional repression. Gene Ontology (GO) annotations related to this gene include cation transmembrane transporter activity and ion transmembrane transporter activity. An important paralog of this gene is SFXN1.

Full Name

sideroflexin 3

Function

Mitochondrial serine transporter that mediates transport of serine into mitochondria, an important step of the one-carbon metabolism pathway (PubMed:30442778).
Mitochondrial serine is converted to glycine and formate, which then exits to the cytosol where it is used to generate the charged folates that serve as one-carbon donors (PubMed:30442778).

Biological Process

Biological Process mitochondrial transmembrane transportManual Assertion Based On ExperimentIDA:UniProtKB
Biological Process one-carbon metabolic processManual Assertion Based On ExperimentIDA:UniProtKB
Biological Process serine import into mitochondrionManual Assertion Based On ExperimentIDA:UniProtKB

Anti-SFXN3 antibodies

Mouse Anti-SFXN3 Recombinant Antibody (CBXS-0330) (CBMAB-S3301-CQ)

Datasheet

SDS

Target: SFXN3

Host: Mouse

Antibody Isotype: IgG2b, κ

Specificity: Human

Clone: CBXS-0330

Application*: SE, WB, E

Rabbit Anti-SFXN3 Recombinant Antibody (CBXS-1370) (CBMAB-S4228-CQ)

Datasheet

SDS

Target: SFXN3

Host: Rabbit

Antibody Isotype: IgG

Specificity: Mouse, Rat, Human

Clone: CBXS-1370

Application*: WB, P

Mouse Anti-SFXN3 Recombinant Antibody (CBXS-3155) (CBMAB-S5897-CQ)

Datasheet

SDS

Target: SFXN3

Host: Mouse

Antibody Isotype: IgG2b, κ

Specificity: Human

Clone: CBXS-3155

Application*: E, WB

For Research Use Only. Not For Clinical Use.

(P): Predicted

* Abbreviations

IFImmunofluorescence

IHImmunohistochemistry

IPImmunoprecipitation

WBWestern Blot

EELISA

MMicroarray

CIChromatin Immunoprecipitation

FFlow Cytometry

FNFunction Assay

IDImmunodiffusion

RRadioimmunoassay

TCTissue Culture

GSGel Supershift

NNeutralization

BBlocking

AActivation

IInhibition

DDepletion

ESELISpot

DBDot Blot

MCMass Cytometry/CyTOF

CTCytotoxicity

SStimulation

AGAgonist

APApoptosis

IMImmunomicroscopy

BABioassay

CSCostimulation

EMElectron Microscopy

IEImmunoelectrophoresis

PAPeptide Array

ICImmunocytochemistry

PEPeptide ELISA

MDMeDIP

SHIn situ hybridization

IAEnzyme Immunoassay

SEsandwich ELISA

PLProximity Ligation Assay

ECELISA(Cap)

EDELISA(Det)

BIBioimaging

IOImmunoassay

LFLateral Flow Immunoassay

LALuminex Assay

CImmunohistochemistry-Frozen Sections

PImmunohistologyp-Paraffin Sections

ISIntracellular Staining for Flow Cytometry

MSElectrophoretic Mobility Shift Assay

RIRNA Binding Protein Immunoprecipitation (RIP)