SH3GLB1

This gene encodes a SRC homology 3 domain-containing protein. The encoded protein interacts with the proapoptotic member of the Bcl-2 family, Bcl-2-associated X protein (Bax) and may be involved in regulating apoptotic signaling pathways. This protein may also be involved in maintaining mitochondrial morphology. Alternate splicing results in multiple transcript variants.

Full Name

SH3-domain GRB2-like endophilin B1

Function

May be required for normal outer mitochondrial membrane dynamics (PubMed:15452144).
Required for coatomer-mediated retrograde transport in certain cells (By similarity).
May recruit other proteins to membranes with high curvature. May promote membrane fusion (PubMed:11604418).
Involved in activation of caspase-dependent apoptosis by promoting BAX/BAK1 activation (PubMed:16227588).
Isoform 1 acts proapoptotic in fibroblasts (By similarity).
Involved in caspase-independent apoptosis during nutrition starvation and involved in the regulation of autophagy. Activates lipid kinase activity of PIK3C3 during autophagy probably by associating with the PI3K complex II (PI3KC3-C2) (PubMed:17891140).
Associated with PI3KC3-C2 during autophagy may regulate the trafficking of ATG9A from the Golgi complex to the peripheral cytoplasm for the formation of autophagosomes by inducing Golgi membrane tubulation and fragmentation (PubMed:21068542).
Involved in regulation of degradative endocytic trafficking and cytokinesis, probably in the context of PI3KC3-C2 (PubMed:20643123).
Isoform 2 acts antiapoptotic in neuronal cells; involved in maintenance of mitochondrial morphology and promotes neuronal viability (By similarity).

Biological Process

Biological Process apoptotic processIEA:UniProtKB-KW
Biological Process autophagic cell deathManual Assertion Based On ExperimentIMP:UniProtKB
Biological Process autophagyIEA:UniProtKB-KW
Biological Process cellular response to amino acid starvationManual Assertion Based On ExperimentIMP:UniProtKB
Biological Process cellular response to glucose starvationManual Assertion Based On ExperimentIMP:UniProtKB
Biological Process membrane fissionManual Assertion Based On ExperimentIMP:UniProtKB
Biological Process membrane organizationManual Assertion Based On ExperimentIBA:GO_Central
Biological Process positive regulation of autophagosome assemblyManual Assertion Based On ExperimentIMP:UniProtKB
Biological Process positive regulation of autophagyManual Assertion Based On ExperimentIMP:UniProtKB
Biological Process positive regulation of membrane tubulationManual Assertion Based On ExperimentIMP:UniProtKB
Biological Process positive regulation of protein targeting to mitochondrionManual Assertion Based On ExperimentHMP:ParkinsonsUK-UCL
Biological Process positive regulation of protein-containing complex assemblyManual Assertion Based On ExperimentIDA:UniProtKB
Biological Process protein localization to vacuolar membraneManual Assertion Based On ExperimentIMP:UniProtKB
Biological Process receptor catabolic processManual Assertion Based On ExperimentIMP:UniProtKB
Biological Process regulation of cytokinesisManual Assertion Based On ExperimentIMP:UniProtKB
Biological Process regulation of macroautophagyManual Assertion Based On ExperimentTAS:ParkinsonsUK-UCL
Biological Process regulation of protein stabilityManual Assertion Based On ExperimentHMP:ParkinsonsUK-UCL

Cellular Location

Cytoplasm
Golgi apparatus membrane
Mitochondrion outer membrane
Cytoplasmic vesicle, autophagosome membrane
Midbody
Association with the Golgi apparatus depends on the cell type (By similarity).
Following starvation colocalizes with ATG5 and LC3 autophagy-related protein(s)on autophagosomal membranes (PubMed:17891140).

PTM

Phosphorylated at Thr-145 by CDK5; this phosphorylation is required for autophagy induction in starved neurons and facilitates homodimerization.