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Mouse Anti-SH3GLB1 Recombinant Antibody (CBXS-4682) (CBMAB-S1917-CQ)

This product is a mouse antibody that recognizes SH3GLB1. The antibody CBXS-4682 can be used for immunoassay techniques such as: WB, IHC, IP.
See all SH3GLB1 antibodies

Summary

Host Animal
Mouse
Specificity
Human
Clone
CBXS-4682
Antibody Isotype
IgG1, κ
Application
WB, IHC, IP

Basic Information

Immunogen
A Full length human Bif-1 recombinant protein was used as immunogen
Specificity
Human
Antibody Isotype
IgG1, κ
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Buffer
PBS, 0.05% BSA
Preservative
0.05% sodium azide
Concentration
0.5 mg/mL
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
SH3-domain GRB2-like endophilin B1
Introduction
This gene encodes a SRC homology 3 domain-containing protein. The encoded protein interacts with the proapoptotic member of the Bcl-2 family, Bcl-2-associated X protein (Bax) and may be involved in regulating apoptotic signaling pathways. This protein may also be involved in maintaining mitochondrial morphology. Alternate splicing results in multiple transcript variants.
Entrez Gene ID
51100
UniProt ID
Q9Y371
Alternative Names
SH3 Domain Containing GRB2 Like, Endophilin B1; Protein Phosphatase 1, Regulatory Subunit 70; SH3 Domain-Containing GRB2-Like Protein B1; Bax-Interacting Factor 1; Bif-1; SH3-Domain, GRB2-Like, Endophilin B1; SH3-Domain GRB2 Like Endophilin B1; Testicular Tissue Protein Li 172;
Function
May be required for normal outer mitochondrial membrane dynamics (PubMed:15452144).
Required for coatomer-mediated retrograde transport in certain cells (By similarity).
May recruit other proteins to membranes with high curvature. May promote membrane fusion (PubMed:11604418).
Involved in activation of caspase-dependent apoptosis by promoting BAX/BAK1 activation (PubMed:16227588).
Isoform 1 acts proapoptotic in fibroblasts (By similarity).
Involved in caspase-independent apoptosis during nutrition starvation and involved in the regulation of autophagy. Activates lipid kinase activity of PIK3C3 during autophagy probably by associating with the PI3K complex II (PI3KC3-C2) (PubMed:17891140).
Associated with PI3KC3-C2 during autophagy may regulate the trafficking of ATG9A from the Golgi complex to the peripheral cytoplasm for the formation of autophagosomes by inducing Golgi membrane tubulation and fragmentation (PubMed:21068542).
Involved in regulation of degradative endocytic trafficking and cytokinesis, probably in the context of PI3KC3-C2 (PubMed:20643123).
Isoform 2 acts antiapoptotic in neuronal cells; involved in maintenance of mitochondrial morphology and promotes neuronal viability (By similarity).
Biological Process
Biological Process apoptotic processIEA:UniProtKB-KW
Biological Process autophagic cell deathManual Assertion Based On ExperimentIMP:UniProtKB
Biological Process autophagyIEA:UniProtKB-KW
Biological Process cellular response to amino acid starvationManual Assertion Based On ExperimentIMP:UniProtKB
Biological Process cellular response to glucose starvationManual Assertion Based On ExperimentIMP:UniProtKB
Biological Process membrane fissionManual Assertion Based On ExperimentIMP:UniProtKB
Biological Process membrane organizationManual Assertion Based On ExperimentIBA:GO_Central
Biological Process positive regulation of autophagosome assemblyManual Assertion Based On ExperimentIMP:UniProtKB
Biological Process positive regulation of autophagyManual Assertion Based On ExperimentIMP:UniProtKB
Biological Process positive regulation of membrane tubulationManual Assertion Based On ExperimentIMP:UniProtKB
Biological Process positive regulation of protein targeting to mitochondrionManual Assertion Based On ExperimentHMP:ParkinsonsUK-UCL
Biological Process positive regulation of protein-containing complex assemblyManual Assertion Based On ExperimentIDA:UniProtKB
Biological Process protein localization to vacuolar membraneManual Assertion Based On ExperimentIMP:UniProtKB
Biological Process receptor catabolic processManual Assertion Based On ExperimentIMP:UniProtKB
Biological Process regulation of cytokinesisManual Assertion Based On ExperimentIMP:UniProtKB
Biological Process regulation of macroautophagyManual Assertion Based On ExperimentTAS:ParkinsonsUK-UCL
Biological Process regulation of protein stabilityManual Assertion Based On ExperimentHMP:ParkinsonsUK-UCL
Cellular Location
Cytoplasm
Golgi apparatus membrane
Mitochondrion outer membrane
Cytoplasmic vesicle, autophagosome membrane
Midbody
Association with the Golgi apparatus depends on the cell type (By similarity).
Following starvation colocalizes with ATG5 and LC3 autophagy-related protein(s)on autophagosomal membranes (PubMed:17891140).
PTM
Phosphorylated at Thr-145 by CDK5; this phosphorylation is required for autophagy induction in starved neurons and facilitates homodimerization.
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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