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SIRT5

This gene encodes a member of the sirtuin family of proteins, homologs to the yeast Sir2 protein. Members of the sirtuin family are characterized by a sirtuin core domain and grouped into four classes. The functions of human sirtuins have not yet been determined; however, yeast sirtuin proteins are known to regulate epigenetic gene silencing and suppress recombination of rDNA. Studies suggest that the human sirtuins may function as intracellular regulatory proteins with mono-ADP-ribosyltransferase activity. The protein encoded by this gene is included in class III of the sirtuin family. Alternative splicing of this gene results in multiple transcript variants. [provided by RefSeq, Jul 2010]
Full Name
Sirtuin 5
Function
NAD-dependent lysine demalonylase, desuccinylase and deglutarylase that specifically removes malonyl, succinyl and glutaryl groups on target proteins (PubMed:21908771, PubMed:22076378, PubMed:24703693, PubMed:29180469).
Activates CPS1 and contributes to the regulation of blood ammonia levels during prolonged fasting: acts by mediating desuccinylation and deglutarylation of CPS1, thereby increasing CPS1 activity in response to elevated NAD levels during fasting (PubMed:22076378, PubMed:24703693).
Activates SOD1 by mediating its desuccinylation, leading to reduced reactive oxygen species (PubMed:24140062).
Activates SHMT2 by mediating its desuccinylation (PubMed:29180469).
Modulates ketogenesis through the desuccinylation and activation of HMGCS2 (By similarity).
Has weak NAD-dependent protein deacetylase activity; however this activity may not be physiologically relevant in vivo. Can deacetylate cytochrome c (CYCS) and a number of other proteins in vitro such as UOX.
Biological Process
Biological Process mitochondrion organizationTAS:Reactome
Biological Process negative regulation of cardiac muscle cell apoptotic processIEA:Ensembl
Biological Process negative regulation of reactive oxygen species metabolic processManual Assertion Based On ExperimentIDA:UniProtKB
Biological Process peptidyl-lysine demalonylationManual Assertion Based On ExperimentIDA:UniProtKB
Biological Process peptidyl-lysine desuccinylationManual Assertion Based On ExperimentIDA:UniProtKB
Biological Process protein ADP-ribosylationBy SimilarityISS:GO_Central
Biological Process protein deacetylationManual Assertion Based On ExperimentIDA:UniProtKB
Biological Process protein deglutarylationManual Assertion Based On ExperimentIDA:UniProtKB
Biological Process protein demalonylationManual Assertion Based On ExperimentIDA:UniProtKB
Biological Process protein desuccinylationManual Assertion Based On ExperimentIDA:UniProtKB
Biological Process regulation of ketone biosynthetic processISS:UniProtKB
Biological Process response to nutrient levelsIEA:Ensembl
Cellular Location
Mitochondrion matrix
Mitochondrion intermembrane space
Cytoplasm, cytosol
Nucleus
Mainly mitochondrial. Also present extramitochondrially, with a fraction present in the cytosol and very small amounts also detected in the nucleus.
Isoform 1
Cytoplasm
Mitochondrion
Isoform 2
Mitochondrion

Anti-SIRT5 antibodies

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Target: SIRT5
Host: Rabbit
Antibody Isotype: IgG
Specificity: Human, Mouse, Monkey
Clone: D5E11
Application*: WB
Target: SIRT5
Host: Rabbit
Antibody Isotype: IgG
Specificity: Human, Mouse, Rat
Clone: D8C3
Application*: WB
Target: SIRT5
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBXS-3828
Application*: F, IF, WB
Target: SIRT5
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBXS-4175
Application*: F, WB
Target: SIRT5
Host: Mouse
Antibody Isotype: IgG2b
Specificity: Human
Clone: CBXS-4197
Application*: F, WB
Target: SIRT5
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBXS-4337
Application*: F, IF, P, WB
Target: SIRT5
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBXS-4442
Application*: F, IF, WB
Target: SIRT5
Host: Mouse
Antibody Isotype: IgG2a
Specificity: Human
Clone: CBXS-4519
Application*: F, WB
Target: SIRT5
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBXS-4527
Application*: IF, WB
Target: SIRT5
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human, Rat, Monkey
Clone: CBXS-4569
Application*: WB, F, IH, IF, P
Target: SIRT5
Host: Rabbit
Antibody Isotype: IgG
Specificity: Human, Mouse, Monkey
Clone: CBXS-5409
Application*: WB
Target: SIRT5
Host: Rabbit
Antibody Isotype: IgG
Specificity: Human, Mouse, Rat
Clone: CBXS-5443
Application*: WB
Target: SIRT5
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBXS-0395
Application*: IP
Target: SIRT5
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBXS-0396
Application*: P, IP
Target: SIRT5
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBXS-0397
Application*: E
Target: SIRT5
Host: Rabbit
Antibody Isotype: IgG
Specificity: Mouse, Human
Clone: CBXS-1530
Application*: WB
Target: SIRT5
Host: Mouse
Antibody Isotype: IgG2b, κ
Specificity: Human
Clone: S5R37-3
Application*: E, WB
Target: SIRT5
Host: Mouse
Antibody Isotype: IgG2a
Specificity: Human
Clone: 1D4
Application*: IP, M
For Research Use Only. Not For Clinical Use.
(P): Predicted
* Abbreviations
IFImmunofluorescence
IHImmunohistochemistry
IPImmunoprecipitation
WBWestern Blot
EELISA
MMicroarray
CIChromatin Immunoprecipitation
FFlow Cytometry
FNFunction Assay
IDImmunodiffusion
RRadioimmunoassay
TCTissue Culture
GSGel Supershift
NNeutralization
BBlocking
AActivation
IInhibition
DDepletion
ESELISpot
DBDot Blot
MCMass Cytometry/CyTOF
CTCytotoxicity
SStimulation
AGAgonist
APApoptosis
IMImmunomicroscopy
BABioassay
CSCostimulation
EMElectron Microscopy
IEImmunoelectrophoresis
PAPeptide Array
ICImmunocytochemistry
PEPeptide ELISA
MDMeDIP
SHIn situ hybridization
IAEnzyme Immunoassay
SEsandwich ELISA
PLProximity Ligation Assay
ECELISA(Cap)
EDELISA(Det)
BIBioimaging
IOImmunoassay
LFLateral Flow Immunoassay
LALuminex Assay
CImmunohistochemistry-Frozen Sections
PImmunohistologyp-Paraffin Sections
ISIntracellular Staining for Flow Cytometry
MSElectrophoretic Mobility Shift Assay
RIRNA Binding Protein Immunoprecipitation (RIP)
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