SLC22A13

This gene encodes a member of the organic-cation transporter family. It is located in a gene cluster with another member of the family, organic cation transporter like 4. The encoded protein is a transmembrane protein involved in the transport of small molecules. This protein can function to mediate urate uptake and is a high affinity nicotinate exchanger in the kidneys and the intestine. [provided by RefSeq]

Full Name

solute carrier family 22 (organic anion transporter), member 13

Function

Anion antiporter that mediates the transport of urate, orotate and nicotinate in exchange for organic or inorganic anions (PubMed:18411268, PubMed:35144162, PubMed:31780526, PubMed:35462902).
Translocates urate and orotate across the apical membrane of proximal tubule epithelial cells and involved in urate renal reabsorption (PubMed:18411268, PubMed:35144162, PubMed:31780526).
Possibly involved in orotate renal reabsorption and nicotinate intestinal reabsorption (PubMed:18411268, PubMed:35144162).
Mediates urate uptake by an exchange with organic anions such as (S)-lactate, succinate, glutathione and nicotinate (PubMed:18411268).
Urate and orotate transports are Cl--dependent (PubMed:35144162, PubMed:35462902).
Shows similar transport characteristics as the urate/orotate renal antiporter SLC22A12/URAT1 and may act as a compensator of SLC22A12/URAT1 in certain conditions (Probable).

Biological Process

Biological Process NAD biosynthesis via nicotinamide riboside salvage pathwayTAS:Reactome
Biological Process negative regulation of fatty acid metabolic processManual Assertion Based On ExperimentIDA:UniProtKB
Biological Process nicotinate transportManual Assertion Based On ExperimentIDA:UniProtKB
Biological Process positive regulation of T cell mediated cytotoxicity directed against tumor cell targetManual Assertion Based On ExperimentIDA:UniProtKB
Biological Process urate transportManual Assertion Based On ExperimentIDA:UniProtKB

Cellular Location

Apical cell membrane

PTM

Glycosylated.