SLC22A13

This gene encodes a member of the organic-cation transporter family. It is located in a gene cluster with another member of the family, organic cation transporter like 4. The encoded protein is a transmembrane protein involved in the transport of small molecules. This protein can function to mediate urate uptake and is a high affinity nicotinate exchanger in the kidneys and the intestine. [provided by RefSeq]

solute carrier family 22 (organic anion transporter), member 13

Anion antiporter that mediates the transport of urate, orotate and nicotinate in exchange for organic or inorganic anions (PubMed:18411268, PubMed:35144162, PubMed:31780526, PubMed:35462902).
Translocates urate and orotate across the apical membrane of proximal tubule epithelial cells and involved in urate renal reabsorption (PubMed:18411268, PubMed:35144162, PubMed:31780526).
Possibly involved in orotate renal reabsorption and nicotinate intestinal reabsorption (PubMed:18411268, PubMed:35144162).
Mediates urate uptake by an exchange with organic anions such as (S)-lactate, succinate, glutathione and nicotinate (PubMed:18411268).
Urate and orotate transports are Cl--dependent (PubMed:35144162, PubMed:35462902).
Shows similar transport characteristics as the urate/orotate renal antiporter SLC22A12/URAT1 and may act as a compensator of SLC22A12/URAT1 in certain conditions (Probable).

Biological Process NAD biosynthesis via nicotinamide riboside salvage pathwayTAS:Reactome
Biological Process negative regulation of fatty acid metabolic processManual Assertion Based On ExperimentIDA:UniProtKB
Biological Process nicotinate transportManual Assertion Based On ExperimentIDA:UniProtKB
Biological Process positive regulation of T cell mediated cytotoxicity directed against tumor cell targetManual Assertion Based On ExperimentIDA:UniProtKB
Biological Process urate transportManual Assertion Based On ExperimentIDA:UniProtKB

Apical cell membrane

Glycosylated.