Mouse Anti-SLC22A13 Recombinant Antibody (CBXS-2767) (CBMAB-S5518-CQ)

Name: Mouse Anti-SLC22A13 Recombinant Antibody (CBXS-2767)
SKU: CBMAB-S5518-CQ
Rating: 5 (1 reviews)

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Datasheet

SDS

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Basic Information

Host Animal

Mouse

Clone

CBXS-2767

Application

ELISA, WB

Immunogen

Partial recombinant corresponding to aa38-139 from SLC22A13 (NP_004247) with GST tag

Specificity

Human

Antibody Isotype

IgG2a, κ

Clonality

Monoclonal

Application Notes

The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format

Liquid

Buffer

PBS, pH 7.2

Storage

Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

More Infomation

Target

Full Name

solute carrier family 22 (organic anion transporter), member 13

Introduction

This gene encodes a member of the organic-cation transporter family. It is located in a gene cluster with another member of the family, organic cation transporter like 4. The encoded protein is a transmembrane protein involved in the transport of small molecules. This protein can function to mediate urate uptake and is a high affinity nicotinate exchanger in the kidneys and the intestine.

Entrez Gene ID

9390

UniProt ID

Q9Y226

Alternative Names

Solute Carrier Family 22 Member 13; Solute Carrier Family 22 (Organic Anion/Urate Transporter), Member 13; Solute Carrier Family 22 (Organic Anion Transporter), Member 13; Organic Cationic Transporter-Like 3; ORCTL-3; ORCTL3;

Function

Anion antiporter that mediates the transport of urate, orotate and nicotinate in exchange for organic or inorganic anions (PubMed:18411268, PubMed:35144162, PubMed:31780526, PubMed:35462902).
Translocates urate and orotate across the apical membrane of proximal tubule epithelial cells and involved in urate renal reabsorption (PubMed:18411268, PubMed:35144162, PubMed:31780526).
Possibly involved in orotate renal reabsorption and nicotinate intestinal reabsorption (PubMed:18411268, PubMed:35144162).
Mediates urate uptake by an exchange with organic anions such as (S)-lactate, succinate, glutathione and nicotinate (PubMed:18411268).
Urate and orotate transports are Cl--dependent (PubMed:35144162, PubMed:35462902).
Shows similar transport characteristics as the urate/orotate renal antiporter SLC22A12/URAT1 and may act as a compensator of SLC22A12/URAT1 in certain conditions (Probable).

Biological Process

Biological Process NAD biosynthesis via nicotinamide riboside salvage pathwayTAS:Reactome
Biological Process negative regulation of fatty acid metabolic processManual Assertion Based On ExperimentIDA:UniProtKB
Biological Process nicotinate transportManual Assertion Based On ExperimentIDA:UniProtKB
Biological Process positive regulation of T cell mediated cytotoxicity directed against tumor cell targetManual Assertion Based On ExperimentIDA:UniProtKB
Biological Process urate transportManual Assertion Based On ExperimentIDA:UniProtKB

Cellular Location

Apical cell membrane

PTM

Glycosylated.

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Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme Linked Immunospot (ELISpot)
Proteogenomic
Other Protocols

Isotype control

For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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