SLC35D2

Nucleotide sugars, which are synthesized in the cytosol or the nucleus, are high-energy donor substrates for glycosyltransferases located in the lumen of the endoplasmic reticulum and Golgi apparatus. Translocation of nucleotide sugars from the cytosol into the lumen compartment is mediated by specific nucleotide sugar transporters, such as SLC35D2 (Suda et al., 2004 [PubMed 15082721]).[supplied by OMIM

Full Name

solute carrier family 35, member D2

Function

Antiporter transporting nucleotide sugars such as UDP-N-acetylglucosamine (UDP-GlcNAc), UDP-glucose (UDP-Glc) and GDP-mannose (GDP-Man) pooled in the cytosol into the lumen of the Golgi in exchange for the corresponding nucleosides monophosphates (UMP for UDP-sugars and GMP for GDP-sugars). May take part in heparan sulfate synthesis by supplying UDP-Glc-NAc, the donor substrate, and thus be involved in growth factor signaling.

Biological Process

Biological Process carbohydrate transportIEA:UniProtKB-KW
Biological Process glycosaminoglycan biosynthetic processTAS:Reactome
Biological Process keratan sulfate biosynthetic processTAS:Reactome

Cellular Location

Golgi apparatus membrane

Topology

Cytoplasmic: 1-27
Helical: 28-48
Extracellular: 49-53
Helical: 54-74
Cytoplasmic: 75-146
Helical: 147-188
Cytoplasmic: 189-201
Helical: 202-222
Extracellular: 223-237
Helical: 238-258
Cytoplasmic: 259-265
Helical: 266-288
Extracellular: 289-292
Helical: 293-315
Cytoplasmic: 316-337