SLITRK5

Members of the SLITRK family, such as SLITRK5, are integral membrane proteins with 2 N-terminal leucine-rich repeat (LRR) domains similar to those of SLIT proteins (see SLIT1; MIM 603742). Most SLITRKs, including SLITRK5, also have C-terminal regions that share homology with neurotrophin receptors (see NTRK1; MIM 191315). SLITRKs are expressed predominantly in neural tissues and have neurite-modulating activity (Aruga et al., 2003 [PubMed 14557068]).

Full Name

SLIT And NTRK Like Family Member 5

Function

Suppresses neurite outgrowth.

Biological Process

Biological Process adult behaviorIEA:Ensembl
Biological Process axonogenesisManual Assertion Based On ExperimentIBA:GO_Central
Biological Process chemical synaptic transmissionIEA:Ensembl
Biological Process circulatory system developmentIEA:Ensembl
Biological Process dendrite morphogenesisIEA:Ensembl
Biological Process grooming behaviorIEA:Ensembl
Biological Process positive regulation of synapse assemblyManual Assertion Based On ExperimentIBA:GO_Central
Biological Process regulation of presynapse assemblyIEA:InterPro
Biological Process response to xenobiotic stimulusIEA:Ensembl
Biological Process skin developmentIEA:Ensembl
Biological Process striatum developmentIEA:Ensembl

Cellular Location

Membrane

Topology

Extracellular: 41-664
Helical: 665-685
Cytoplasmic: 686-958