SMC1B

SMC1L2 belongs to a family of proteins required for chromatid cohesion and DNA recombination during meiosis and mitosis (3:Revenkova et al., 2001 [PubMed 11564881]).
Full Name
Structural Maintenance Of Chromosomes 1B
Function
Meiosis-specific component of cohesin complex. Required for the maintenance of meiotic cohesion, but not, or only to a minor extent, for its establishment. Contributes to axial element (AE) formation and the organization of chromatin loops along the AE. Plays a key role in synapsis, recombination and chromosome movements. The cohesin complex is required for the cohesion of sister chromatids after DNA replication. The cohesin complex apparently forms a large proteinaceous ring within which sister chromatids can be trapped. At anaphase, the complex is cleaved and dissociates from chromatin, allowing sister chromatids to segregate. The meiosis-specific cohesin complex probably replaces mitosis specific cohesin complex when it dissociates from chromatin during prophase I (By similarity).
Biological Process
Biological Process meiotic cell cycleIEA:UniProtKB-KW
Biological Process sister chromatid cohesionManual Assertion Based On ExperimentIBA:GO_Central
Cellular Location
Nucleus
Chromosome
Chromosome, centromere
Associates with chromatin. In prophase I stage of meiosis, localizes along the AE of synaptonemal complexes. In late-pachytene-diplotene, the bulk of protein dissociates from the chromosome arms probably because of phosphorylation by PLK, except at centromeres, where cohesin complexes remain. Remains chromatin associated at the centromeres up to metaphase II. At anaphase II, dissociates from centromeres, allowing chromosomes segregation (By similarity).
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Anti-SMC1B antibodies

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Mouse Anti-SMC1B Recombinant Antibody (CBXS-3327) (CBMAB-S6065-CQ)

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Target: SMC1B
Host: Mouse
Antibody Isotype: IgG1, κ
Specificity: Human
Clone: CBXS-3327
Application*: E, IF, WB
Datasheet SDS

Rabbit Anti-SMC1B Recombinant Antibody (CBXS-1516) (CBMAB-S4369-CQ)

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Target: SMC1B
Host: Rabbit
Antibody Isotype: IgG
Specificity: Human
Clone: CBXS-1516
Application*: WB, P
Datasheet SDS

Rabbit Anti-SMC1B Recombinant Antibody (CBXS-1469) (CBMAB-S4324-CQ)

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Target: SMC1B
Host: Rabbit
Antibody Isotype: IgG
Specificity: Mouse, Rat, Human
Clone: CBXS-1469
Application*: WB, IP, P
Datasheet SDS

Rabbit Anti-SMC1B Recombinant Antibody (CBXS-1468) (CBMAB-S4323-CQ)

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Target: SMC1B
Host: Rabbit
Antibody Isotype: IgG
Specificity: Human
Clone: CBXS-1468
Application*: WB, P, IC
Datasheet SDS

Rabbit Anti-SMC1B Recombinant Antibody (CBXS-1235) (CBMAB-S4096-CQ)

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Target: SMC1B
Host: Rabbit
Antibody Isotype: IgG
Specificity: Human
Clone: CBXS-1235
Application*: WB, IP
Datasheet SDS

Rabbit Anti-SMC1B Recombinant Antibody (CBXS-1199) (CBMAB-S4065-CQ)

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Target: SMC1B
Host: Rabbit
Antibody Isotype: IgG
Specificity: Mouse, Human
Clone: CBXS-1199
Application*: WB, IF
Datasheet SDS

Rabbit Anti-SMC1B Recombinant Antibody (CBXS-1198) (CBMAB-S4064-CQ)

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Target: SMC1B
Host: Rabbit
Antibody Isotype: IgG
Specificity: Human
Clone: CBXS-1198
Application*: WB, IF
Datasheet SDS

Rabbit Anti-SMC1B Recombinant Antibody (CBXS-1197) (CBMAB-S4063-CQ)

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Target: SMC1B
Host: Rabbit
Antibody Isotype: IgG
Specificity: Human
Clone: CBXS-1197
Application*: WB, IP
Datasheet SDS
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(P): Predicted
* Abbreviations
  • AActivation
  • AGAgonist
  • APApoptosis
  • BBlocking
  • BABioassay
  • BIBioimaging
  • CImmunohistochemistry-Frozen Sections
  • CIChromatin Immunoprecipitation
  • CTCytotoxicity
  • CSCostimulation
  • DDepletion
  • DBDot Blot
  • EELISA
  • ECELISA(Cap)
  • EDELISA(Det)
  • ESELISpot
  • EMElectron Microscopy
  • FFlow Cytometry
  • FNFunction Assay
  • GSGel Supershift
  • IInhibition
  • IAEnzyme Immunoassay
  • ICImmunocytochemistry
  • IDImmunodiffusion
  • IEImmunoelectrophoresis
  • IFImmunofluorescence
  • IHImmunohistochemistry
  • IMImmunomicroscopy
  • IOImmunoassay
  • IPImmunoprecipitation
  • ISIntracellular Staining for Flow Cytometry
  • LALuminex Assay
  • LFLateral Flow Immunoassay
  • MMicroarray
  • MCMass Cytometry/CyTOF
  • MDMeDIP
  • MSElectrophoretic Mobility Shift Assay
  • NNeutralization
  • PImmunohistologyp-Paraffin Sections
  • PAPeptide Array
  • PEPeptide ELISA
  • PLProximity Ligation Assay
  • RRadioimmunoassay
  • SStimulation
  • SESandwich ELISA
  • SHIn situ hybridization
  • TCTissue Culture
  • WBWestern Blot
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