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Rabbit Anti-SMC1B Recombinant Antibody (CBXS-1199) (CBMAB-S4065-CQ)

This product is a rabbit antibody that recognizes SMC1B. The antibody CBXS-1199 can be used for immunoassay techniques such as: WB, IF.
See all SMC1B antibodies

Summary

Host Animal
Rabbit
Specificity
Mouse, Human
Clone
CBXS-1199
Antibody Isotype
IgG
Application
WB, IF

Basic Information

Specificity
Mouse, Human
Antibody Isotype
IgG
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
Structural Maintenance Of Chromosomes 1B
Introduction
SMC1L2 belongs to a family of proteins required for chromatid cohesion and DNA recombination during meiosis and mitosis (3:Revenkova et al., 2001 [PubMed 11564881]).
Entrez Gene ID
Human27127
Mouse140557
UniProt ID
HumanQ8NDV3
MouseQ920F6
Alternative Names
Structural Maintenance Of Chromosomes 1B; SMC1 (Structural Maintenance Of Chromosomes 1, Yeast)-Like 1; SMC Protein 1B; SMC1L2; Mitosis-Specific Chromosome Segregation Protein Like Protein Beta; SMC1 Structural Maintenance Of Chromosomes 1-Like 2 (Yeast);
Function
Meiosis-specific component of cohesin complex. Required for the maintenance of meiotic cohesion, but not, or only to a minor extent, for its establishment. Contributes to axial element (AE) formation and the organization of chromatin loops along the AE. Plays a key role in synapsis, recombination and chromosome movements. The cohesin complex is required for the cohesion of sister chromatids after DNA replication. The cohesin complex apparently forms a large proteinaceous ring within which sister chromatids can be trapped. At anaphase, the complex is cleaved and dissociates from chromatin, allowing sister chromatids to segregate. The meiosis-specific cohesin complex probably replaces mitosis specific cohesin complex when it dissociates from chromatin during prophase I (By similarity).
Biological Process
Biological Process meiotic cell cycleIEA:UniProtKB-KW
Biological Process sister chromatid cohesionManual Assertion Based On ExperimentIBA:GO_Central
Cellular Location
Nucleus
Chromosome
Chromosome, centromere
Associates with chromatin. In prophase I stage of meiosis, localizes along the AE of synaptonemal complexes. In late-pachytene-diplotene, the bulk of protein dissociates from the chromosome arms probably because of phosphorylation by PLK, except at centromeres, where cohesin complexes remain. Remains chromatin associated at the centromeres up to metaphase II. At anaphase II, dissociates from centromeres, allowing chromosomes segregation (By similarity).
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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