SNRPA

The protein encoded by this gene associates with stem loop II of the U1 small nuclear ribonucleoprotein, which binds the 5' splice site of precursor mRNAs and is required for splicing. The encoded protein autoregulates itself by polyadenylation inhibition of its own pre-mRNA via dimerization and has been implicated in the coupling of splicing and polyadenylation. [provided by RefSeq, Oct 2010]
Full Name
Small Nuclear Ribonucleoprotein Polypeptide A
Function
Component of the spliceosomal U1 snRNP, which is essential for recognition of the pre-mRNA 5' splice-site and the subsequent assembly of the spliceosome. U1 snRNP is the first snRNP to interact with pre-mRNA. This interaction is required for the subsequent binding of U2 snRNP and the U4/U6/U5 tri-snRNP. SNRPA binds stem loop II of U1 snRNA. In a snRNP-free form (SF-A) may be involved in coupled pre-mRNA splicing and polyadenylation process. May bind preferentially to the 5'-UGCAC-3' motif on RNAs.
Biological Process
Biological Process mRNA splicing, via spliceosomeManual Assertion Based On ExperimentIBA:GO_Central
Biological Process regulation of mRNA polyadenylationIEA:Ensembl
Cellular Location
Nucleus
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Anti-SNRPA antibodies

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SNRPA Matched Antibody Pair (1115) (APMAB-1115LY)

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Target: SNRPA
Specificity: Human
Datasheet SDS

SNRPA Matched Antibody Pair (1114) (APMAB-1114LY)

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Target: SNRPA
Specificity: Human
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Mouse Anti-SNRPA Recombinant Antibody (CBXS-2139) (CBMAB-S4903-CQ)

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Target: SNRPA
Host: Mouse
Specificity: Mouse
Clone: CBXS-2139
Application*: WB, IP, IF, E
Datasheet SDS

Rabbit Anti-SNRPA Recombinant Antibody (CBXS-1574) (CBMAB-S4423-CQ)

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Target: SNRPA
Host: Rabbit
Antibody Isotype: IgG
Specificity: Mouse, Rat, Human
Clone: CBXS-1574
Application*: WB, IP, P, IC
Datasheet SDS

Rabbit Anti-SNRPA Recombinant Antibody (CBXS-1573) (CBMAB-S4422-CQ)

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Target: SNRPA
Host: Rabbit
Antibody Isotype: IgG
Specificity: Mouse, Rat, Human
Clone: CBXS-1573
Application*: WB, P
Datasheet SDS

Mouse Anti-SNRPA (AA 1-283) Recombinant Antibody (CBXS-0616) (CBMAB-S3558-CQ)

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Target: SNRPA
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBXS-0616
Application*: E, IC, IH, WB
Datasheet SDS

Mouse Anti-SNRPA Recombinant Antibody (CBXS-0615) (CBMAB-S3557-CQ)

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Target: SNRPA
Host: Mouse
Antibody Isotype: IgG1, κ
Specificity: Human
Clone: CBXS-0615
Application*: E, WB, P, IF
Datasheet SDS

Mouse Anti-SNRPA Recombinant Antibody (CBXS-5616) (CBMAB-S0494-CQ)

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Target: SNRPA
Host: Mouse
Antibody Isotype: IgG1, κ
Specificity: Human
Clone: CBXS-5616
Application*: E, IF, P, WB
Datasheet SDS

Mouse Anti-SNRPA Recombinant Antibody (CBFYS-004) (CBMAB-S0004-FY)

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Target: SNRPA
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBFYS-004
Application*: WB, P, F, IF
Datasheet SDS

Rabbit Anti-SNRPA Recombinant Antibody (CBFYS-003) (CBMAB-S0003-FY)

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Target: SNRPA
Host: Rabbit
Antibody Isotype: IgG
Specificity: Mouse, Rat, Human
Clone: CBFYS-003
Application*: WB, IP, IF
Datasheet SDS

Mouse Anti-SNRPA Recombinant Antibody (3F9-1F7) (CBMAB-S0002-FY)

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Target: SNRPA
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: 3F9-1F7
Application*: WB, P, IF, SE
Datasheet SDS
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(P): Predicted
* Abbreviations
  • AActivation
  • AGAgonist
  • APApoptosis
  • BBlocking
  • BABioassay
  • BIBioimaging
  • CImmunohistochemistry-Frozen Sections
  • CIChromatin Immunoprecipitation
  • CTCytotoxicity
  • CSCostimulation
  • DDepletion
  • DBDot Blot
  • EELISA
  • ECELISA(Cap)
  • EDELISA(Det)
  • ESELISpot
  • EMElectron Microscopy
  • FFlow Cytometry
  • FNFunction Assay
  • GSGel Supershift
  • IInhibition
  • IAEnzyme Immunoassay
  • ICImmunocytochemistry
  • IDImmunodiffusion
  • IEImmunoelectrophoresis
  • IFImmunofluorescence
  • IGImmunochromatography
  • IHImmunohistochemistry
  • IMImmunomicroscopy
  • IOImmunoassay
  • IPImmunoprecipitation
  • ISIntracellular Staining for Flow Cytometry
  • LALuminex Assay
  • LFLateral Flow Immunoassay
  • MMicroarray
  • MCMass Cytometry/CyTOF
  • MDMeDIP
  • MSElectrophoretic Mobility Shift Assay
  • NNeutralization
  • PImmunohistologyp-Paraffin Sections
  • PAPeptide Array
  • PEPeptide ELISA
  • PLProximity Ligation Assay
  • RRadioimmunoassay
  • SStimulation
  • SESandwich ELISA
  • SHIn situ hybridization
  • TCTissue Culture
  • WBWestern Blot
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