SOCS2

This gene encodes a member of the STAT-induced STAT inhibitor (SSI), also known as suppressor of cytokine signaling (SOCS), family. SSI family members are cytokine-inducible negative regulators of cytokine signaling. The expression of this gene can be induced by a subset of cytokines, including erythropoietin, GM-CSF, IL10 and interferon (IFN)-gamma. The protein encoded by this gene is found to interact with the cytoplasmic domain of insulin-like growth factor-1 receptor (IGF1R), and thus is thought to be involved in the regulation of IGF1R mediated cell signaling. Knockout studies in mice also suggested a regulatory role of this gene in IGF-1 related growth control. [provided by RefSeq]

Full Name

SOCS2

Function

SOCS family proteins form part of a classical negative feedback system that regulates cytokine signal transduction. SOCS2 appears to be a negative regulator in the growth hormone/IGF1 signaling pathway. Probable substrate recognition component of a SCF-like ECS (Elongin BC-CUL2/5-SOCS-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins.

Biological Process

Biological Process cellular response to hormone stimulusManual Assertion Based On ExperimentIDA:BHF-UCL
Biological Process growth hormone receptor signaling pathwayManual Assertion Based On ExperimentIDA:BHF-UCL
Biological Process intracellular signal transductionIEA:Ensembl
Biological Process lactationIEA:Ensembl
Biological Process mammary gland alveolus developmentIEA:Ensembl
Biological Process negative regulation of apoptotic processManual Assertion Based On ExperimentTAS:ProtInc
Biological Process negative regulation of multicellular organism growthIEA:Ensembl
Biological Process negative regulation of receptor signaling pathway via JAK-STATIEA:Ensembl
Biological Process phosphatidylinositol phosphate biosynthetic processManual Assertion Based On ExperimentIBA:GO_Central
Biological Process positive regulation of neuron differentiationIEA:Ensembl
Biological Process protein ubiquitinationIEA:UniProtKB-UniPathway
Biological Process receptor signaling pathway via JAK-STATManual Assertion Based On ExperimentTAS:ProtInc
Biological Process regulation of cell growth1 PublicationNAS:UniProtKB
Biological Process regulation of signal transduction1 PublicationNAS:UniProtKB
Biological Process response to estradiolManual Assertion Based On ExperimentIDA:BHF-UCL

Cellular Location

cytoplasm
cytosol
phosphatidylinositol 3-kinase complex

PTM

Ubiquitinated; mediated by AREL1 and leading to its subsequent proteasomal degradation (PubMed:31578312).
Ubiquitination is dependent on its phosphorylation at Ser-52, by PKC (PubMed:31578312).
Ubiquitination is stimulated by LPS (By similarity).
Phosphorylation at Ser-52 by PKC facilitates its ubiquitination and proteosomal degradation.