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SOCS2

This gene encodes a member of the STAT-induced STAT inhibitor (SSI), also known as suppressor of cytokine signaling (SOCS), family. SSI family members are cytokine-inducible negative regulators of cytokine signaling. The expression of this gene can be induced by a subset of cytokines, including erythropoietin, GM-CSF, IL10 and interferon (IFN)-gamma. The protein encoded by this gene is found to interact with the cytoplasmic domain of insulin-like growth factor-1 receptor (IGF1R), and thus is thought to be involved in the regulation of IGF1R mediated cell signaling. Knockout studies in mice also suggested a regulatory role of this gene in IGF-1 related growth control. [provided by RefSeq]
Full Name
SOCS2
Function
SOCS family proteins form part of a classical negative feedback system that regulates cytokine signal transduction. SOCS2 appears to be a negative regulator in the growth hormone/IGF1 signaling pathway. Probable substrate recognition component of a SCF-like ECS (Elongin BC-CUL2/5-SOCS-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins.
Biological Process
Biological Process cellular response to hormone stimulusManual Assertion Based On ExperimentIDA:BHF-UCL
Biological Process growth hormone receptor signaling pathwayManual Assertion Based On ExperimentIDA:BHF-UCL
Biological Process intracellular signal transductionIEA:Ensembl
Biological Process lactationIEA:Ensembl
Biological Process mammary gland alveolus developmentIEA:Ensembl
Biological Process negative regulation of apoptotic processManual Assertion Based On ExperimentTAS:ProtInc
Biological Process negative regulation of multicellular organism growthIEA:Ensembl
Biological Process negative regulation of receptor signaling pathway via JAK-STATIEA:Ensembl
Biological Process phosphatidylinositol phosphate biosynthetic processManual Assertion Based On ExperimentIBA:GO_Central
Biological Process positive regulation of neuron differentiationIEA:Ensembl
Biological Process protein ubiquitinationIEA:UniProtKB-UniPathway
Biological Process receptor signaling pathway via JAK-STATManual Assertion Based On ExperimentTAS:ProtInc
Biological Process regulation of cell growth1 PublicationNAS:UniProtKB
Biological Process regulation of signal transduction1 PublicationNAS:UniProtKB
Biological Process response to estradiolManual Assertion Based On ExperimentIDA:BHF-UCL
Cellular Location
cytoplasm
cytosol
phosphatidylinositol 3-kinase complex
PTM
Ubiquitinated; mediated by AREL1 and leading to its subsequent proteasomal degradation (PubMed:31578312).
Ubiquitination is dependent on its phosphorylation at Ser-52, by PKC (PubMed:31578312).
Ubiquitination is stimulated by LPS (By similarity).
Phosphorylation at Ser-52 by PKC facilitates its ubiquitination and proteosomal degradation.

Anti-SOCS2 antibodies

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Target: SOCS2
Host: Mouse
Antibody Isotype: IgG
Specificity: Human
Clone: 17F3
Application*: E, M
Target: SOCS2
Host: Mouse
Antibody Isotype: IgG2a, κ
Specificity: Human
Clone: 3E7
Application*: SE, E
Target: SOCS2
Host: Mouse
Antibody Isotype: IgG2a, κ
Specificity: Human
Clone: CBXS-0631
Application*: E
Target: SOCS2
Host: Rabbit
Antibody Isotype: IgG
Specificity: Human
Clone: CBXS-1459
Application*: WB, IP, IF
Target: SOCS2
Host: Mouse
Antibody Isotype: IgG2b
Specificity: Human
Clone: CBXS-1845
Application*: WB
Target: SOCS2
Host: Rabbit
Antibody Isotype: IgG
Specificity: Human
Clone: EPR2588(2)
Application*: IP, IC, IF, WB
For Research Use Only. Not For Clinical Use.
(P): Predicted
* Abbreviations
IFImmunofluorescence
IHImmunohistochemistry
IPImmunoprecipitation
WBWestern Blot
EELISA
MMicroarray
CIChromatin Immunoprecipitation
FFlow Cytometry
FNFunction Assay
IDImmunodiffusion
RRadioimmunoassay
TCTissue Culture
GSGel Supershift
NNeutralization
BBlocking
AActivation
IInhibition
DDepletion
ESELISpot
DBDot Blot
MCMass Cytometry/CyTOF
CTCytotoxicity
SStimulation
AGAgonist
APApoptosis
IMImmunomicroscopy
BABioassay
CSCostimulation
EMElectron Microscopy
IEImmunoelectrophoresis
PAPeptide Array
ICImmunocytochemistry
PEPeptide ELISA
MDMeDIP
SHIn situ hybridization
IAEnzyme Immunoassay
SEsandwich ELISA
PLProximity Ligation Assay
ECELISA(Cap)
EDELISA(Det)
BIBioimaging
IOImmunoassay
LFLateral Flow Immunoassay
LALuminex Assay
CImmunohistochemistry-Frozen Sections
PImmunohistologyp-Paraffin Sections
ISIntracellular Staining for Flow Cytometry
MSElectrophoretic Mobility Shift Assay
RIRNA Binding Protein Immunoprecipitation (RIP)
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