Mouse Anti-SOCS2 Recombinant Antibody (3E7) (CBMAB-A8444-LY)

Name: Mouse Anti-SOCS2 Recombinant Antibody (3E7)
SKU: CBMAB-A8444-LY
Rating: 5 (1 reviews)

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Datasheet

SDS

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Datasheet Target Q & As Review & reward Protocols Associated Products

Basic Information

Host Animal

Mouse

Clone

3E7

Application

sELISA, ELISA

Immunogen

SOCS2 (AAH10399, 99 a.a. ~ 198 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.

Specificity

Human

Antibody Isotype

IgG2a, κ

Clonality

Monoclonal

Application Notes

The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format

Liquid

Purity

> 95% Purity determined by SDS-PAGE.

Storage

Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freezethaw cycles.

More Infomation

Target

Full Name

SOCS2

Introduction

This gene encodes a member of the STAT-induced STAT inhibitor (SSI), also known as suppressor of cytokine signaling (SOCS), family. SSI family members are cytokine-inducible negative regulators of cytokine signaling. The expression of this gene can be induced by a subset of cytokines, including erythropoietin, GM-CSF, IL10 and interferon (IFN)-gamma. The protein encoded by this gene is found to interact with the cytoplasmic domain of insulin-like growth factor-1 receptor (IGF1R), and thus is thought to be involved in the regulation of IGF1R mediated cell signaling. Knockout studies in mice also suggested a regulatory role of this gene in IGF-1 related growth control. [provided by RefSeq]

Entrez Gene ID

8835

UniProt ID

O14508

Alternative Names

CIS2; Cish2; SOCS-2; SSI-2; SSI2; STATI2

Function

SOCS family proteins form part of a classical negative feedback system that regulates cytokine signal transduction. SOCS2 appears to be a negative regulator in the growth hormone/IGF1 signaling pathway. Probable substrate recognition component of a SCF-like ECS (Elongin BC-CUL2/5-SOCS-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins.

Biological Process

Biological Process cellular response to hormone stimulusManual Assertion Based On ExperimentIDA:BHF-UCL
Biological Process growth hormone receptor signaling pathwayManual Assertion Based On ExperimentIDA:BHF-UCL
Biological Process intracellular signal transductionIEA:Ensembl
Biological Process lactationIEA:Ensembl
Biological Process mammary gland alveolus developmentIEA:Ensembl
Biological Process negative regulation of apoptotic processManual Assertion Based On ExperimentTAS:ProtInc
Biological Process negative regulation of multicellular organism growthIEA:Ensembl
Biological Process negative regulation of receptor signaling pathway via JAK-STATIEA:Ensembl
Biological Process phosphatidylinositol phosphate biosynthetic processManual Assertion Based On ExperimentIBA:GO_Central
Biological Process positive regulation of neuron differentiationIEA:Ensembl
Biological Process protein ubiquitinationIEA:UniProtKB-UniPathway
Biological Process receptor signaling pathway via JAK-STATManual Assertion Based On ExperimentTAS:ProtInc
Biological Process regulation of cell growth1 PublicationNAS:UniProtKB
Biological Process regulation of signal transduction1 PublicationNAS:UniProtKB
Biological Process response to estradiolManual Assertion Based On ExperimentIDA:BHF-UCL

Cellular Location

cytoplasm
cytosol
phosphatidylinositol 3-kinase complex

PTM

Ubiquitinated; mediated by AREL1 and leading to its subsequent proteasomal degradation (PubMed:31578312).
Ubiquitination is dependent on its phosphorylation at Ser-52, by PKC (PubMed:31578312).
Ubiquitination is stimulated by LPS (By similarity).
Phosphorylation at Ser-52 by PKC facilitates its ubiquitination and proteosomal degradation.

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Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme-Linked Immunospot (ELISpot)
Proteogenomics
Other Protocols

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Isotype control

For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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