SPCS2

SPCS2 (Signal Peptidase Complex Subunit 2) is a Protein Coding gene. Diseases associated with SPCS2 include Neuronal Ceroid Lipofuscinosis. Among its related pathways are Peptide hormone metabolism and Gene Expression. Gene Ontology (GO) annotations related to this gene include peptidase activity.

Full Name

Signal Peptidase Complex Subunit 2

Function

Component of the signal peptidase complex (SPC) which catalyzes the cleavage of N-terminal signal sequences from nascent proteins as they are translocated into the lumen of the endoplasmic reticulum (PubMed:34388369).
Enhances the enzymatic activity of SPC and facilitates the interactions between different components of the translocation site (By similarity).

Biological Process

Biological Process protein targeting to ERManual Assertion Based On ExperimentIBA:GO_Central
Biological Process signal peptide processingManual Assertion Based On ExperimentIDA:ComplexPortal

Cellular Location

Endoplasmic reticulum membrane

Topology

Cytoplasmic: 2-86
Helical: 87-107
Lumenal: 108-111
Helical: 112-132
Cytoplasmic: 133-226

Anti-SPCS2 antibodies

Mouse Anti-SPCS2 Recombinant Antibody (CBXS-4062) (CBMAB-S1321-CQ)

Datasheet

SDS

Target: SPCS2

Host: Mouse

Antibody Isotype: IgG2a

Specificity: Human

Clone: CBXS-4062

Application*: WB

For Research Use Only. Not For Clinical Use.

(P): Predicted

* Abbreviations

IFImmunofluorescence

IHImmunohistochemistry

IPImmunoprecipitation

WBWestern Blot

EELISA

MMicroarray

CIChromatin Immunoprecipitation

FFlow Cytometry

FNFunction Assay

IDImmunodiffusion

RRadioimmunoassay

TCTissue Culture

GSGel Supershift

NNeutralization

BBlocking

AActivation

IInhibition

DDepletion

ESELISpot

DBDot Blot

MCMass Cytometry/CyTOF

CTCytotoxicity

SStimulation

AGAgonist

APApoptosis

IMImmunomicroscopy

BABioassay

CSCostimulation

EMElectron Microscopy

IEImmunoelectrophoresis

PAPeptide Array

ICImmunocytochemistry

PEPeptide ELISA

MDMeDIP

SHIn situ hybridization

IAEnzyme Immunoassay

SEsandwich ELISA

PLProximity Ligation Assay

ECELISA(Cap)

EDELISA(Det)

BIBioimaging

IOImmunoassay

LFLateral Flow Immunoassay

LALuminex Assay

CImmunohistochemistry-Frozen Sections

PImmunohistologyp-Paraffin Sections

ISIntracellular Staining for Flow Cytometry

MSElectrophoretic Mobility Shift Assay

RIRNA Binding Protein Immunoprecipitation (RIP)