SPCS2

SPCS2 (Signal Peptidase Complex Subunit 2) is a Protein Coding gene. Diseases associated with SPCS2 include Neuronal Ceroid Lipofuscinosis. Among its related pathways are Peptide hormone metabolism and Gene Expression. Gene Ontology (GO) annotations related to this gene include peptidase activity.

Full Name

Signal Peptidase Complex Subunit 2

Function

Component of the signal peptidase complex (SPC) which catalyzes the cleavage of N-terminal signal sequences from nascent proteins as they are translocated into the lumen of the endoplasmic reticulum (PubMed:34388369).
Enhances the enzymatic activity of SPC and facilitates the interactions between different components of the translocation site (By similarity).

Biological Process

Biological Process protein targeting to ERManual Assertion Based On ExperimentIBA:GO_Central
Biological Process signal peptide processingManual Assertion Based On ExperimentIDA:ComplexPortal

Cellular Location

Endoplasmic reticulum membrane

Topology

Cytoplasmic: 2-86
Helical: 87-107
Lumenal: 108-111
Helical: 112-132
Cytoplasmic: 133-226