Mouse Anti-SPCS2 Recombinant Antibody (CBXS-4062) (CBMAB-S1321-CQ)

Name: Mouse Anti-SPCS2 Recombinant Antibody (CBXS-4062)
SKU: CBMAB-S1321-CQ
Rating: 5 (1 reviews)

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Datasheet

SDS

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Basic Information

Host Animal

Mouse

Clone

CBXS-4062

Application

Immunogen

Human recombinant protein fragment corresponding to amino acids 2-64 of human SPCS2 (NP_055567)

Specificity

Human

Antibody Isotype

IgG2a

Application Notes

The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Storage

Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

More Infomation

Target

Full Name

Signal Peptidase Complex Subunit 2

Introduction

SPCS2 (Signal Peptidase Complex Subunit 2) is a Protein Coding gene. Diseases associated with SPCS2 include Neuronal Ceroid Lipofuscinosis. Among its related pathways are Peptide hormone metabolism and Gene Expression. Gene Ontology (GO) annotations related to this gene include peptidase activity.

Entrez Gene ID

9789

UniProt ID

Q15005

Alternative Names

Signal Peptidase Complex Subunit 2; Signal Peptidase Complex Subunit 2 Homolog (S. Cerevisiae); Microsomal Signal Peptidase 25 KDa Subunit; Signal Peptidase 25kDa Subunit; SPase 25 KDa Subunit; EC 3.4.-.-; KIAA0102; SPC25;

Function

Component of the signal peptidase complex (SPC) which catalyzes the cleavage of N-terminal signal sequences from nascent proteins as they are translocated into the lumen of the endoplasmic reticulum (PubMed:34388369).
Enhances the enzymatic activity of SPC and facilitates the interactions between different components of the translocation site (By similarity).

Biological Process

Biological Process protein targeting to ERManual Assertion Based On ExperimentIBA:GO_Central
Biological Process signal peptide processingManual Assertion Based On ExperimentIDA:ComplexPortal

Cellular Location

Endoplasmic reticulum membrane

Topology

Cytoplasmic: 2-86
Helical: 87-107
Lumenal: 108-111
Helical: 112-132
Cytoplasmic: 133-226

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Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme-Linked Immunospot (ELISpot)
Proteogenomics
Other Protocols

Isotype control

For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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