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Mouse Anti-SPCS2 Recombinant Antibody (CBXS-4062) (CBMAB-S1321-CQ)

This product is a mouse antibody that recognizes SPCS2. The antibody CBXS-4062 can be used for immunoassay techniques such as: WB.
See all SPCS2 antibodies

Summary

Host Animal
Mouse
Specificity
Human
Clone
CBXS-4062
Antibody Isotype
IgG2a
Application
WB

Basic Information

Immunogen
Human recombinant protein fragment corresponding to amino acids 2-64 of human SPCS2 (NP_055567)
Specificity
Human
Antibody Isotype
IgG2a
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
Signal Peptidase Complex Subunit 2
Introduction
SPCS2 (Signal Peptidase Complex Subunit 2) is a Protein Coding gene. Diseases associated with SPCS2 include Neuronal Ceroid Lipofuscinosis. Among its related pathways are Peptide hormone metabolism and Gene Expression. Gene Ontology (GO) annotations related to this gene include peptidase activity.
Entrez Gene ID
9789
UniProt ID
Q15005
Alternative Names
Signal Peptidase Complex Subunit 2; Signal Peptidase Complex Subunit 2 Homolog (S. Cerevisiae); Microsomal Signal Peptidase 25 KDa Subunit; Signal Peptidase 25kDa Subunit; SPase 25 KDa Subunit; EC 3.4.-.-; KIAA0102; SPC25;
Function
Component of the signal peptidase complex (SPC) which catalyzes the cleavage of N-terminal signal sequences from nascent proteins as they are translocated into the lumen of the endoplasmic reticulum (PubMed:34388369).
Enhances the enzymatic activity of SPC and facilitates the interactions between different components of the translocation site (By similarity).
Biological Process
Biological Process protein targeting to ERManual Assertion Based On ExperimentIBA:GO_Central
Biological Process signal peptide processingManual Assertion Based On ExperimentIDA:ComplexPortal
Cellular Location
Endoplasmic reticulum membrane
Topology
Cytoplasmic: 2-86
Helical: 87-107
Lumenal: 108-111
Helical: 112-132
Cytoplasmic: 133-226
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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