SPOCK2

This gene encodes a protein which binds with glycosaminoglycans to form part of the extracellular matrix. The protein contains thyroglobulin type-1, follistatin-like, and calcium-binding domains, and has glycosaminoglycan attachment sites in the acidic C-terminal region. Three alternatively spliced transcript variants that encode different protein isoforms have been described for this gene.

Full Name

SPARC/Osteonectin, Cwcv And Kazal Like Domains Proteoglycan 2

Function

May participate in diverse steps of neurogenesis. Binds calcium.

Biological Process

Biological Process cellular response to leukemia inhibitory factorIEA:Ensembl
Biological Process extracellular matrix organization1 PublicationNAS:UniProtKB
Biological Process negative regulation of endopeptidase activityManual Assertion Based On ExperimentTAS:ParkinsonsUK-UCL
Biological Process peptide cross-linking via chondroitin 4-sulfate glycosaminoglycanIEA:Ensembl
Biological Process positive regulation of cell motilityManual Assertion Based On ExperimentTAS:ParkinsonsUK-UCL
Biological Process positive regulation of cell-substrate adhesionIEA:Ensembl
Biological Process regulation of cell differentiation1 PublicationNAS:UniProtKB
Biological Process synapse assembly1 PublicationNAS:UniProtKB

Cellular Location

Secreted, extracellular space, extracellular matrix

PTM

Contains chondroitin sulfate and heparan sulfate O-linked oligosaccharides.